{"id":"W4380361287","doi":"10.1093/neuonc/noad073.015","title":"ATRT-15. ATRTS HIJACK EPIGENETIC MECHANISMS TO PROMOTE IMMUNOSUPPRESSION AND ESCAPE FROM NK CELL THERAPY","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Chromatin; Biology; Enhancer; Chromatin remodeling; Cancer research; Epigenetics; Cell biology; Gene silencing; Histone; Transcription factor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583437,0.0002272043,0.0002572586,0.00005868153,0.0001190572,0.00002603416,0.0002413557,0.0003056994,0.0000926572],"category_scores_gemma":[0.0000531385,0.000208513,0.00008574027,0.0001355326,0.00004566616,0.000003370508,0.0002769606,0.000150372,0.0001205316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002903998,"about_ca_system_score_gemma":0.000131591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006333281,"about_ca_topic_score_gemma":0.00002944636,"domain_scores_codex":[0.9984177,0.00015091,0.0002647053,0.000646317,0.0001457612,0.0003746104],"domain_scores_gemma":[0.9991807,0.00005870169,0.00009292181,0.0004565184,0.00005527664,0.0001558275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001527491,0.00004876986,0.00006301755,0.00001098589,0.0000184104,0.00002064024,0.000206936,0.0002120454,0.9339908,0.000002952709,0.005983715,0.05928893],"study_design_scores_gemma":[0.001062804,0.001392979,0.0003392786,0.00001522728,0.00001623571,0.00001576753,0.00007390589,0.0009853881,0.8581133,0.0005560615,0.1371997,0.000229292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994684,0.001674122,0.0009432838,0.0009340877,0.0006953335,0.0003898978,0.00003475727,0.00007057961,0.0005739492],"genre_scores_gemma":[0.9901147,0.004371577,0.002740066,0.001833901,0.0003470308,0.00007723078,0.0001448044,0.00006612534,0.0003045525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.131216,"threshold_uncertainty_score":0.8502913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01451055439331619,"score_gpt":0.2749306572841261,"score_spread":0.26042010289081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}