{"id":"W4380361287","doi":"10.1093/neuonc/noad073.015","title":"ATRT-15. ATRTS HIJACK EPIGENETIC MECHANISMS TO PROMOTE IMMUNOSUPPRESSION AND ESCAPE FROM NK CELL THERAPY","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Chromatin; Biology; Enhancer; Chromatin remodeling; Cancer research; Epigenetics; Cell biology; Gene silencing; Histone; Transcription factor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001409298,0.0002066726,0.0002599189,0.0001372855,0.0001059622,0.0003219705,0.0001982953,0.0002050564,0.003095028],"category_scores_gemma":[0.00008741593,0.00008652259,0.0002089016,0.0001053341,0.0001927554,0.0001744833,0.0002109122,0.0006895129,0.0009417924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001938302,"about_ca_system_score_gemma":0.0001718953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001430647,"about_ca_topic_score_gemma":0.0003239049,"domain_scores_codex":[0.9998662,0.00002053889,0.00001336707,0.00002746846,0.00003541381,0.0000369632],"domain_scores_gemma":[0.9999278,0.000007293394,0.00002078965,0.0000135536,0.000005708148,0.00002498236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002799725,0.0001269017,0.0007759403,0.00006600451,0.00001788966,0.0001209097,0.00001831808,0.0002633441,0.9880531,0.0005534829,0.0003479529,0.009376221],"study_design_scores_gemma":[0.0001591334,0.002462484,0.007613219,0.00001872761,0.00005612208,0.00169461,0.00005087659,0.001886226,0.9629901,0.0003053635,0.02275469,0.000008399375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870007,0.002796745,0.003513499,0.0002335618,0.00008704303,0.0000773469,0.000649756,0.0003291185,0.005312266],"genre_scores_gemma":[0.9940157,0.0005031503,0.001209093,0.00008171014,0.00001373624,0.00004255897,0.0005410307,0.00002101502,0.003572003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003095028,"threshold_uncertainty_score":0.01035392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01451055439331619,"score_gpt":0.2749306572841261,"score_spread":0.26042010289081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}