{"id":"W4380364471","doi":"10.14309/ajg.0000000000002355","title":"Association of Alanine Aminotransferase Flares to Hepatitis B Surface Decline During Tenofovir Alone or With Pegylated Interferon Alfa","year":2023,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Institutes of Health; Novo Nordisk; National Center for Advancing Translational Sciences; Moderna; Genentech; Georgia Clinical and Translational Science Alliance; National Institute of Diabetes and Digestive and Kidney Diseases; Gilead Sciences; GlaxoSmithKline; Bristol-Myers Squibb","keywords":"Medicine; Pegylated interferon; Tenofovir; Alanine aminotransferase; Virology; Internal medicine; Alanine; Ribavirin; Chronic hepatitis; Pharmacology; Human immunodeficiency virus (HIV); Genetics; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008334738,0.0001649473,0.0003291725,0.0002788385,0.0002180393,0.0004086422,0.0001494503,0.0003186709,0.002058197],"category_scores_gemma":[0.003118545,0.0001239484,0.0003886314,0.0002958161,0.0001354619,0.0003140207,0.0001993889,0.0004782541,0.0001122597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002229201,"about_ca_system_score_gemma":0.0002200469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00155483,"about_ca_topic_score_gemma":0.002049659,"domain_scores_codex":[0.9995944,0.0001137691,0.00004980392,0.00007381547,0.00006725784,0.0001010819],"domain_scores_gemma":[0.9973602,0.0006928486,0.001223164,0.00008672869,0.0001861534,0.0004508865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001635317,0.00006600685,0.9956802,0.00001266222,0.00007653775,0.00004875086,0.00002995041,0.00004518415,0.0004084996,0.000006795703,0.00004039134,0.001949719],"study_design_scores_gemma":[0.00001437229,0.0004768743,0.9989488,0.000003718282,0.00003226941,0.0001238182,0.00004046438,0.0001613483,0.0001100527,0.000008761048,0.00007752526,0.000002064621],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995395,0.0002111382,0.00002507014,0.00001644013,0.000002524575,0.000002566918,0.00003809914,0.000001056148,0.0001637575],"genre_scores_gemma":[0.9998084,0.00002890916,0.00001475769,0.000008176527,0.00000656027,0.00000170543,0.0000639591,5.546433e-7,0.00006713317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002058197,"threshold_uncertainty_score":0.006885409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178074691163876,"score_gpt":0.2652104088400927,"score_spread":0.253429661928454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}