{"id":"W4380365659","doi":"10.1093/neuonc/noad073.214","title":"LGG-04. CLINICALLY RELEVANT MODELING OF FUSION-DRIVEN PEDIATRIC LOW GRADE GLIOMAS USING DROSOPHILA MELANOGASTER","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Drosophila melanogaster; Biology; Model organism; Zebrafish; Phenotype; Melanogaster; Glioma; Fusion protein; Fusion gene; Mdm2; Signal transduction; Cancer research; Gene; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001536891,0.0005070176,0.0001977714,0.0003933307,0.0002378003,0.000344375,0.0006194356,0.0006886074,0.003942964],"category_scores_gemma":[0.0001193415,0.0002172025,0.0004359889,0.0001405053,0.0002203022,0.0001491428,0.0003263757,0.0007021955,0.0009250609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006087251,"about_ca_system_score_gemma":0.0002979633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00371609,"about_ca_topic_score_gemma":0.003347325,"domain_scores_codex":[0.9999143,0.00001442088,0.000007808827,0.00002137305,0.00002871087,0.00001328866],"domain_scores_gemma":[0.9999162,0.00002105502,0.00002209223,0.00001038643,0.00001115878,0.00001915678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001803158,0.000128571,0.001425149,0.0002657078,0.00002449,0.0005492887,0.00007140308,0.01823568,0.9684231,0.00321735,0.001809129,0.005669853],"study_design_scores_gemma":[0.0002236583,0.00100746,0.008582645,0.0001208336,0.0001182156,0.001101941,0.0001754677,0.1745288,0.7297856,0.00159667,0.08269708,0.00006151584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8563908,0.00211667,0.08478437,0.0006421797,0.0002139543,0.0007721052,0.02801085,0.00351138,0.02355766],"genre_scores_gemma":[0.8851547,0.001435726,0.07759217,0.0001815741,0.00001314132,0.00109566,0.01328859,0.0007526799,0.02048558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003942964,"threshold_uncertainty_score":0.01319051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05998903932418236,"score_gpt":0.3444273446007706,"score_spread":0.2844383052765882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}