{"id":"W4380366399","doi":"10.1093/neuonc/noad073.042","title":"BIOL-23. LOSS OF MICRORNAS COOPERATES WITH TUMOR SUPPRESSORS TO INITIATE MYC-DEPENDENT METASTATIC MEDULLOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation","funders":"","keywords":"Dicer; Biology; Cancer research; Medulloblastoma; PTEN; Gene silencing; microRNA; Glioma; Tumor progression; Tumor initiation; Carcinogenesis; Cancer; PI3K/AKT/mTOR pathway; Small interfering RNA; Genetics; Cell culture; Transfection; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003188557,0.0002926569,0.0005093131,0.0001761087,0.00009757189,0.0000154974,0.0003572554,0.0001062658,0.00002588247],"category_scores_gemma":[0.000451228,0.0002452453,0.00008590404,0.0004271825,0.0002643832,0.000004759226,0.0003708893,0.000162541,0.0001818915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003092187,"about_ca_system_score_gemma":0.0002906393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003112304,"about_ca_topic_score_gemma":0.0001960066,"domain_scores_codex":[0.9979555,0.0002871849,0.0004219314,0.0006012052,0.0002021066,0.0005320641],"domain_scores_gemma":[0.9988015,0.0001869397,0.000169751,0.0004039645,0.0002668417,0.0001710575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000463199,0.000123471,0.001319492,0.0000506976,0.0001879118,0.0005064496,0.0004252471,0.0007282319,0.9923874,0.00002829683,0.00339692,0.0003827463],"study_design_scores_gemma":[0.001149504,0.00357383,0.0004801104,0.00002458218,0.00006999405,0.0001959453,0.000388559,0.00002640992,0.95124,0.00002306159,0.04256537,0.0002626062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974797,0.0001837648,0.0002678542,0.0006565266,0.0003365973,0.0004396132,0.0001732913,0.00005939609,0.0004032806],"genre_scores_gemma":[0.9973241,0.0001091572,0.0006068719,0.001440778,0.0001106867,0.0001261452,0.00009102502,0.00006306272,0.0001281584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04114731,"threshold_uncertainty_score":1,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02381797646764164,"score_gpt":0.2944482749256472,"score_spread":0.2706302984580056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}