{"id":"W4380366399","doi":"10.1093/neuonc/noad073.042","title":"BIOL-23. LOSS OF MICRORNAS COOPERATES WITH TUMOR SUPPRESSORS TO INITIATE MYC-DEPENDENT METASTATIC MEDULLOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation","funders":"","keywords":"Dicer; Biology; Cancer research; Medulloblastoma; PTEN; Gene silencing; microRNA; Glioma; Tumor progression; Tumor initiation; Carcinogenesis; Cancer; PI3K/AKT/mTOR pathway; Small interfering RNA; Genetics; Cell culture; Transfection; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001719253,0.0003744579,0.0002489214,0.0003035007,0.0001823026,0.0003689959,0.0002296407,0.0003279249,0.001698871],"category_scores_gemma":[0.0001167719,0.0002416126,0.0003143555,0.00008075705,0.0002163014,0.0001435023,0.0003090662,0.0005756343,0.0009070595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004527423,"about_ca_system_score_gemma":0.0002008402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006051801,"about_ca_topic_score_gemma":0.001299398,"domain_scores_codex":[0.9997724,0.00002729984,0.00002967776,0.00005394652,0.00007310507,0.00004367781],"domain_scores_gemma":[0.9998349,0.00002224843,0.00005132738,0.00002191132,0.000009353832,0.00006028972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003594791,0.00001870045,0.0001371056,0.0000102932,0.000003501107,0.00009185873,0.00000668448,0.00004129517,0.9989686,0.0001210341,0.00003245406,0.0005325673],"study_design_scores_gemma":[0.000009648115,0.0001700034,0.003532341,0.000003627292,0.000008942685,0.000475157,0.00001637932,0.0009493034,0.991243,0.00003805209,0.003550034,0.000003358199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901844,0.0009633227,0.004342736,0.0001206063,0.00006019096,0.00005966324,0.001068132,0.0003354692,0.002865425],"genre_scores_gemma":[0.9925844,0.000271305,0.001693677,0.0000375113,0.000006880227,0.00005069551,0.0007377438,0.00006808874,0.004549646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001698871,"threshold_uncertainty_score":0.005683303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02381797646764164,"score_gpt":0.2944482749256472,"score_spread":0.2706302984580056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}