{"id":"W4380368915","doi":"10.1093/neuonc/noad073.060","title":"DIPG-13. NEW IMMUNOCOMPETENT GENETICALLY-ENGINEERED MOUSE MODELS OF PEDIATRIC-TYPE DIFFUSE HIGH-GRADE GLIOMAS REVEAL MECHANISMS OF TUMOR INITIATION AND PROGRESSION","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Biology; Lineage markers; OLIG2; Cancer research; KRAS; Cell of origin; Glioma; Tumor initiation; IDH1; Pathology; Mutation; Progenitor cell; Oligodendrocyte; Gene; Stem cell; Carcinogenesis; Medicine; Myelin; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006754858,0.001495048,0.0005776754,0.001842788,0.0005037998,0.0009009278,0.0009733323,0.001698142,0.005457934],"category_scores_gemma":[0.0002037865,0.0006579364,0.0007597426,0.0005297359,0.001072979,0.001024971,0.0004756978,0.003140017,0.002304968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009133479,"about_ca_system_score_gemma":0.0005962728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008690382,"about_ca_topic_score_gemma":0.001772678,"domain_scores_codex":[0.9992908,0.00009453535,0.00008639121,0.0002024287,0.0001515016,0.0001742995],"domain_scores_gemma":[0.9994069,0.00006478478,0.0002016025,0.00006697316,0.00004277278,0.0002169272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006867422,0.0005296286,0.0003530289,0.0001681583,0.00002029414,0.0004210109,0.00007740858,0.0003414659,0.9926482,0.001250108,0.0005147294,0.002989215],"study_design_scores_gemma":[0.0003932938,0.002477276,0.005033585,0.0001036922,0.00008257972,0.0017377,0.0001842115,0.003328529,0.9684297,0.0004947997,0.01770343,0.00003120665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9532156,0.003098019,0.02087681,0.001160831,0.0003289349,0.0006510076,0.01120516,0.001500921,0.007962636],"genre_scores_gemma":[0.9263905,0.003197663,0.02400445,0.000575737,0.00008493402,0.001945722,0.009657289,0.000649639,0.03349409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005457934,"threshold_uncertainty_score":0.01825863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02924943784175905,"score_gpt":0.2896653529142814,"score_spread":0.2604159150725224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}