{"id":"W4380371865","doi":"10.1016/j.celrep.2023.112634","title":"Identification of aryl hydrocarbon receptor as a barrier to HIV-1 infection and outgrowth in CD4+ T cells","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Sherbrooke; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; Canadian Institutes of Health Research; Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture; Australian Research Council; Koning Boudewijnstichting; National Heart, Lung, and Blood Institute; Université Libre de Bruxelles; International Association of Sedimentologists; Les Amis des Instituts Pasteur à Bruxelles; European AIDS Treatment Network; Office of Extramural Research, National Institutes of Health; European Commission; McGill University Health Centre; National Institutes of Health; Fondation du CHUM; Waalse Gewest; McGill University; ViiV Healthcare; Thomas Jefferson University; Fonds de Recherche du Québec - Santé; Institut National de la Santé et de la Recherche Médicale; Canadian Foundation for AIDS Research; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Fonds De La Recherche Scientifique - FNRS; Université Laval","keywords":"Aryl hydrocarbon receptor; Biology; Viral replication; Chromatin immunoprecipitation; Vesicular stomatitis virus; T cell; Transcription factor; Virology; Cell biology; Immunology; Promoter; Virus; Immune system; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000816663,0.0001365359,0.0001294243,0.0001430525,0.0001641124,0.0003723799,0.0001198521,0.0001889918,0.001203171],"category_scores_gemma":[0.00007782693,0.0000897482,0.0001398197,0.00009577708,0.000126295,0.0001347491,0.0002303202,0.0005154205,0.0002375528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002533674,"about_ca_system_score_gemma":0.0002612561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006977162,"about_ca_topic_score_gemma":0.000930962,"domain_scores_codex":[0.9999039,0.0000128109,0.000004424882,0.00001884815,0.00002638057,0.00003363133],"domain_scores_gemma":[0.9999481,0.000007149888,0.0000125264,0.000004948928,0.000009407963,0.00001780849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000818702,0.00001737726,0.0008923594,0.00003969332,0.000005627434,0.00004389047,0.00001998037,0.00004838692,0.9948694,0.0002190586,0.00006191125,0.003700608],"study_design_scores_gemma":[0.00005323319,0.0007127313,0.102655,0.00004010683,0.00006838061,0.000751493,0.0003004393,0.003391196,0.8791977,0.0007183514,0.01209375,0.00001768752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871072,0.006172267,0.003139547,0.0002018636,0.00003114117,0.00003056422,0.0002455559,0.000085493,0.00298625],"genre_scores_gemma":[0.9936418,0.001533058,0.001669298,0.0001073,0.0000199126,0.00002907052,0.0003048827,0.000009838366,0.002684794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001203171,"threshold_uncertainty_score":0.004025042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006378525343671259,"score_gpt":0.2246486208889692,"score_spread":0.218270095545298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}