{"id":"W4380372174","doi":"10.1093/neuonc/noad073.083","title":"DIPG-36. H3K27M HISTONE MUTANT GLIOMAS ARE SENSITIVE TO METHIONINE LOSS AND MAT2A INHIBITION THROUGH A NOVEL FEEDBACK MECHANISM BETWEEN AMD1 AND METTL16","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"","keywords":"Methionine Adenosyltransferase; Methionine; Epigenetics; Methyltransferase; Methylation; Histone; Biology; Regulator; Cell biology; Cancer research; Biochemistry; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273023,0.0003261965,0.0002106606,0.0002595153,0.0001258663,0.0002373706,0.0003142893,0.0002335481,0.001044233],"category_scores_gemma":[0.00006430991,0.0001673922,0.0002878961,0.0001219155,0.0002561129,0.0001311906,0.0002450326,0.0004672871,0.0002902782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003164173,"about_ca_system_score_gemma":0.000197465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008678715,"about_ca_topic_score_gemma":0.001183185,"domain_scores_codex":[0.999855,0.00001399465,0.00001304728,0.00003814724,0.00005077447,0.00002900612],"domain_scores_gemma":[0.9998975,0.00001040606,0.000042549,0.00001304559,0.000007631301,0.00002888079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000451304,0.00001159695,0.00008444956,0.00000875415,0.000002073001,0.00002569629,0.00000287923,0.0000297237,0.9994016,0.00005908408,0.00001443018,0.0003146885],"study_design_scores_gemma":[0.000009232272,0.000196606,0.001955744,0.00000190046,0.000006151467,0.0001160962,0.000009718432,0.000785995,0.995968,0.00003636145,0.0009111965,0.000002909233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99224,0.0007603741,0.0047825,0.0001260191,0.00004043083,0.00003662108,0.0006419414,0.0002397421,0.001132506],"genre_scores_gemma":[0.9948032,0.0002611321,0.002217617,0.00004282779,0.000004326724,0.0000377919,0.0003898546,0.00002447108,0.002218866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001044233,"threshold_uncertainty_score":0.003493369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02888501305955689,"score_gpt":0.3151405217067985,"score_spread":0.2862555086472416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}