{"id":"W4380372507","doi":"10.1093/jpp/rgad038","title":"Novel human STING activation by hydrated-prenylated xanthones from <i>Garcinia cowa</i>","year":2023,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Natural Compound Pharmacology Studies","field":"Agricultural and Biological Sciences","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Health Sciences North; National Research Council Canada; Métis National Council","funders":"Vietnam Academy of Science and Technology; Ottawa Hospital Research Institute","keywords":"Xanthone; Sulforhodamine B; Prenylation; Interferon; Cell culture; Tumor necrosis factor alpha; IC50; Cytokine; Pharmacology; Chemistry; Biology; Molecular biology; Biochemistry; In vitro; Cytotoxicity; Enzyme; Immunology; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004486082,0.0002870111,0.0001148963,0.0001348792,0.00008435379,0.00009693656,0.00009342837,0.000128378,0.001192411],"category_scores_gemma":[0.00004314584,0.00004721658,0.0001477743,0.00009523665,0.00009069552,0.0001598316,0.0000934625,0.0001826693,0.0001411877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008592205,"about_ca_system_score_gemma":0.00007308961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001539562,"about_ca_topic_score_gemma":0.000310319,"domain_scores_codex":[0.9999809,0.000004023881,0.000001802349,0.00000442884,0.000003747137,0.000005158091],"domain_scores_gemma":[0.9999795,0.000003165284,0.00000887158,0.000001623512,0.000001779814,0.000005097727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002854748,0.00002748338,0.0002565646,0.0001643317,0.00001233565,0.0001209002,0.00002460673,0.0001654447,0.9946616,0.0000826693,0.00004361529,0.004154888],"study_design_scores_gemma":[0.00006677469,0.001493157,0.006151764,0.00001890014,0.00006206463,0.0003983785,0.00004598119,0.0004069516,0.9849096,0.00008894556,0.006345402,0.00001201114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908935,0.005944424,0.0009001092,0.00008429428,0.00002785539,0.00002773287,0.0002841041,0.00003339295,0.001804622],"genre_scores_gemma":[0.9952421,0.002252839,0.0009680129,0.00005307855,0.00002352206,0.00001475084,0.0003451892,0.000004762041,0.001095719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001192411,"threshold_uncertainty_score":0.003989041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0478596962245901,"score_gpt":0.327393316278113,"score_spread":0.2795336200535229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}