{"id":"W4380373552","doi":"10.1016/j.omtm.2023.06.005","title":"Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"iCo Therapeutics (Canada); University of British Columbia","funders":"Networks of Centres of Excellence of Canada; NanoMedicines Innovation Network; Canadian Institutes of Health Research; University of Pune; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Sphingomyelin; Messenger RNA; Protein expression; Chemistry; Cell biology; Internal medicine; Endocrinology; Biology; Biochemistry; Cholesterol; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002831422,0.0002684191,0.000528045,0.0001074312,0.00006022838,0.00003518268,0.0002501926,0.0002607127,0.00003059014],"category_scores_gemma":[0.0002745498,0.0002329727,0.0001007887,0.0002177635,0.00009546572,0.00001021083,0.000185896,0.0001793117,0.00001359514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002088555,"about_ca_system_score_gemma":0.0001268416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003731792,"about_ca_topic_score_gemma":0.000007142471,"domain_scores_codex":[0.996469,0.001208482,0.001085375,0.0006084052,0.0002467881,0.0003819441],"domain_scores_gemma":[0.998961,0.0001591519,0.0002407839,0.0003999785,0.0001094644,0.0001295896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002127347,0.0001010732,0.003883095,0.00005404286,0.0001100844,0.00002211362,0.0003269094,0.00006221802,0.9173294,0.00003466663,0.00001883921,0.07784482],"study_design_scores_gemma":[0.001273284,0.0005613074,0.02813758,0.0002401119,0.00001053135,0.000002136041,0.0001381402,0.0002309527,0.9647996,0.000221575,0.004074567,0.0003102332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838443,0.002773195,0.01230167,0.00009761546,0.0003262449,0.0005920462,0.000004282184,0.00002818064,0.00003246986],"genre_scores_gemma":[0.9443372,0.0006074205,0.05425261,0.0001809264,0.00007646672,0.0001731196,0.00002361458,0.00004000078,0.0003086711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07753459,"threshold_uncertainty_score":0.950035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09510745692056474,"score_gpt":0.3974518432250009,"score_spread":0.3023443863044362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}