{"id":"W4380373552","doi":"10.1016/j.omtm.2023.06.005","title":"Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"iCo Therapeutics (Canada); University of British Columbia","funders":"Networks of Centres of Excellence of Canada; NanoMedicines Innovation Network; Canadian Institutes of Health Research; University of Pune; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Sphingomyelin; Messenger RNA; Protein expression; Chemistry; Cell biology; Internal medicine; Endocrinology; Biology; Biochemistry; Cholesterol; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001908681,0.0003033202,0.0001808332,0.0001706896,0.0001243537,0.0002671056,0.00009037488,0.0002312492,0.00123814],"category_scores_gemma":[0.0001643584,0.00009700508,0.0001438453,0.00009076647,0.000317398,0.0002039733,0.0001731661,0.0004692128,0.0005114068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003760803,"about_ca_system_score_gemma":0.0003354118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006313171,"about_ca_topic_score_gemma":0.001197594,"domain_scores_codex":[0.9998858,0.00001785298,0.000009422408,0.0000243321,0.00004627259,0.00001629836],"domain_scores_gemma":[0.999894,0.0000256863,0.00002754238,0.00000947614,0.00002517431,0.00001810607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001718065,0.000005942981,0.00003172631,0.00001840759,0.000001013342,0.00001280556,0.00000920431,0.00001961095,0.9988104,0.00005361732,0.00001463701,0.001005391],"study_design_scores_gemma":[0.00000355068,0.0001413689,0.0003880604,0.000002430515,0.00000578433,0.00005681219,0.00001206096,0.000171014,0.997889,0.00001711303,0.001310789,0.000001975567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9696236,0.001496083,0.02225939,0.0002438093,0.00007963576,0.00008812874,0.0002185363,0.0003108555,0.005680003],"genre_scores_gemma":[0.9710575,0.001479726,0.01626223,0.0001073635,0.00002242746,0.00008193,0.0004841039,0.00007585094,0.01042902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00123814,"threshold_uncertainty_score":0.004141986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09510745692056474,"score_gpt":0.3974518432250009,"score_spread":0.3023443863044362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}