{"id":"W4380415292","doi":"10.1021/acs.est.3c00159","title":"Toward a Universal Unit for Quantification of Antibiotic Resistance Genes in Environmental Samples","year":2023,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Pharmaceutical and Antibiotic Environmental Impacts","field":"Environmental Science","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Agriculture and Agri-Food Canada; McGill University","funders":"Eidgenössische Anstalt für Wasserversorgung Abwasserreinigung und Gewässerschutz; Rijksinstituut voor Volksgezondheid en Milieu; Natural Environment Research Council; Medical Research Council; Tsinghua Shenzhen International Graduate School; Universidade Federal do Rio de Janeiro; College of Engineering, Michigan State University; Indian Institute of Technology Delhi; University of Cyprus; Technische Universität Dresden; University of New South Wales; Chung-Ang University; Aalborg Universitet; Engineering and Physical Sciences Research Council; Technische Universiteit Delft; Université de Lyon; Sun Yat-sen University; University of Queensland; Centre National de la Recherche Scientifique; Southern Cross University; University of Hong Kong; Sight Research UK; Michigan State University; Tsinghua University; North-West University; Research Grants Council, University Grants Committee; Wellcome Trust; McGill University; McMaster University","keywords":"Biology; Antibiotic resistance; Comparability; Gene; Human health; Computational biology; Copy-number variation; Biotechnology; Genome; Genetics; Antibiotics; Medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0005919718,0.0002588012,0.0002902115,0.0005285853,0.0002502615,0.00001801931,0.0008665642,0.0001580888,0.0004472231],"category_scores_gemma":[0.00005612049,0.0002564386,0.00007905978,0.001753156,0.00475132,0.0004462252,0.0006715931,0.0001787022,0.000519436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005236768,"about_ca_system_score_gemma":0.00001837859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003188977,"about_ca_topic_score_gemma":0.00003041519,"domain_scores_codex":[0.9973274,0.00003651946,0.0004252032,0.0008141594,0.0005591913,0.0008375567],"domain_scores_gemma":[0.9991253,0.00008248614,0.000171134,0.00045037,0.000001194291,0.0001695118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003487656,0.0002416481,0.1921545,0.00001308762,0.000004871586,0.00001159323,0.0001419518,0.000697247,0.7987687,0.0005238462,0.00005151224,0.007356139],"study_design_scores_gemma":[0.0007937374,0.0001705388,0.4201114,0.00003310764,0.00001862006,0.0000112455,0.001745386,0.001556733,0.5657821,0.001677499,0.007729777,0.0003698063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969183,0.0001333597,0.0004246926,0.0008824825,0.0001063132,0.0005817545,0.0001204934,0.0001041616,0.0007284783],"genre_scores_gemma":[0.9973078,0.0004775842,0.001502459,0.00006114147,0.00001130883,0.00001397326,0.00004046861,0.00002474231,0.0005605248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2329866,"threshold_uncertainty_score":0.9999888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04765167155669942,"score_gpt":0.2882849719941377,"score_spread":0.2406333004374383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}