{"id":"W4380422015","doi":"10.1080/15548627.2023.2224206","title":"PHAF1/MYTHO is a novel autophagy regulator that controls muscle integrity","year":2023,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Horizon 2020 Framework Programme; Fonds de Recherche du Québec - Santé; Associazione Italiana per la Ricerca sul Cancro","keywords":"Autophagy; Biology; mTORC1; Downregulation and upregulation; Skeletal muscle; Cell biology; Muscle atrophy; Regulator; SDHA; Myocyte; Proteostasis; Endocrinology; PI3K/AKT/mTOR pathway; Mitochondrion; Signal transduction; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004940323,0.0004790892,0.0008353543,0.0003385486,0.0002331454,0.00007263673,0.0003628739,0.0003690452,0.00244457],"category_scores_gemma":[0.0001661722,0.0004188498,0.0005139707,0.0008304241,0.0002099961,0.0002677267,0.0001419163,0.0005888374,0.002289386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000148431,"about_ca_system_score_gemma":0.0003428547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009172665,"about_ca_topic_score_gemma":0.000004151136,"domain_scores_codex":[0.9969428,0.00007547219,0.0005334501,0.0007920902,0.0007547637,0.0009014679],"domain_scores_gemma":[0.9977641,0.0002136677,0.0001938656,0.001141987,0.000160731,0.0005256209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002154181,0.003771475,0.006701232,0.0007930913,0.002933345,0.003028889,0.006293457,0.00003596437,0.5742992,0.02429931,0.2460136,0.1296763],"study_design_scores_gemma":[0.01358698,0.0005956942,0.5454469,0.0002718546,0.0004547971,0.0002048813,0.0003595508,0.007507537,0.2304384,0.00519942,0.1950102,0.000923789],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850652,0.001668888,0.0006464164,0.003949294,0.00102162,0.001006403,0.0001716716,0.001606351,0.004864155],"genre_scores_gemma":[0.970306,0.0002160684,0.0005647439,0.00831463,0.0006056165,0.0001577589,0.0001225363,0.0001146999,0.01959791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5387457,"threshold_uncertainty_score":0.9998263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05473673559402828,"score_gpt":0.32541348222956,"score_spread":0.2706767466355318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}