{"id":"W4380422015","doi":"10.1080/15548627.2023.2224206","title":"PHAF1/MYTHO is a novel autophagy regulator that controls muscle integrity","year":2023,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Horizon 2020 Framework Programme; Fonds de Recherche du Québec - Santé; Associazione Italiana per la Ricerca sul Cancro","keywords":"Autophagy; Biology; mTORC1; Downregulation and upregulation; Skeletal muscle; Cell biology; Muscle atrophy; Regulator; SDHA; Myocyte; Proteostasis; Endocrinology; PI3K/AKT/mTOR pathway; Mitochondrion; Signal transduction; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009705903,0.0003357166,0.0003191589,0.0002168151,0.0002687989,0.000296373,0.0002005065,0.000295502,0.0005173945],"category_scores_gemma":[0.0000617812,0.00009018557,0.0002699554,0.0001431636,0.0002549418,0.000222819,0.0002068542,0.0003434247,0.0002075262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003148597,"about_ca_system_score_gemma":0.0002261783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002763407,"about_ca_topic_score_gemma":0.0004887641,"domain_scores_codex":[0.9999349,0.000004381034,0.000004826147,0.00002651439,0.00001652844,0.0000128886],"domain_scores_gemma":[0.9999485,0.000003578293,0.00002600897,0.000003140797,0.000005548583,0.00001321894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001587218,0.00002313362,0.00160485,0.00017123,0.0000149276,0.0004569227,0.00001896091,0.0001220569,0.9855857,0.0005606451,0.000394772,0.01088796],"study_design_scores_gemma":[0.00008670871,0.000726752,0.05240979,0.00007157854,0.00009382039,0.00631745,0.0000774201,0.002630998,0.8763349,0.0007617059,0.06044663,0.00004231386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.910768,0.06108206,0.01642309,0.0007448547,0.000289819,0.0001324873,0.002326232,0.0005691284,0.007664298],"genre_scores_gemma":[0.9685527,0.01319413,0.009700113,0.0003211297,0.00009432547,0.00007597357,0.002643899,0.00004007597,0.005377728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005173945,"threshold_uncertainty_score":0.002284467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05473673559402828,"score_gpt":0.32541348222956,"score_spread":0.2706767466355318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}