{"id":"W4380422111","doi":"10.14336/ad.2023.0424-2","title":"G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer’s Disease","year":2024,"lang":"en","type":"article","venue":"Aging and Disease","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"European Regional Development Fund; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institutes of Health; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Ministerio de Economía y Competitividad; Generalitat de Catalunya; National Natural Science Foundation of China; Agencia Estatal de Investigación; Mental Health Commission","keywords":"Neuroprotection; Epigenetics; Methylation; Gene knockdown; Biology; Caenorhabditis elegans; Downregulation and upregulation; Alzheimer's disease; Neuroscience; Cell biology; Genetics; Gene; Medicine; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009427516,0.0004614752,0.0003285899,0.0002486046,0.0001755297,0.0001854489,0.0001959512,0.0003142872,0.001101638],"category_scores_gemma":[0.00006206535,0.0001035809,0.0003274934,0.0001237882,0.0002200062,0.0001388946,0.0001968818,0.0006270055,0.0003718235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002259739,"about_ca_system_score_gemma":0.0001899973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009201163,"about_ca_topic_score_gemma":0.001795587,"domain_scores_codex":[0.9999429,0.000006653901,0.000006894092,0.00001622963,0.00001082638,0.00001639945],"domain_scores_gemma":[0.9999652,0.000002703254,0.00001020771,0.000003958134,0.000004827182,0.00001309761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004337411,0.00005212153,0.0002139362,0.00009102787,0.00001827287,0.00006675823,0.00001032497,0.00005640708,0.9960979,0.00004482166,0.0001133207,0.002801222],"study_design_scores_gemma":[0.00008560497,0.001054017,0.01468022,0.00002372026,0.00009043877,0.0002785622,0.00003694645,0.000638732,0.9772751,0.0001526893,0.005673062,0.0000108553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889323,0.007210102,0.001271589,0.0002326946,0.00007894626,0.00003044579,0.000640044,0.0002130179,0.00139083],"genre_scores_gemma":[0.99273,0.003349666,0.001296556,0.0001140816,0.00001537598,0.00004422255,0.0005864658,0.00002014692,0.001843417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001101638,"threshold_uncertainty_score":0.003685355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01706525921908648,"score_gpt":0.2740660063328326,"score_spread":0.2570007471137461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}