{"id":"W4380447997","doi":"10.1093/ndt/gfad063b_4394","title":"#4394TACROLIMUS BUT NOT VOCLOSPORIN INHIBITS KIDNEY TUBULAR CALCIUM AND MAGNESIUM REABSORPTION IN RATS AT CLINICALLY THERAPEUTIC DOSES","year":2023,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aurinia (Canada)","funders":"","keywords":"Medicine; Hypomagnesemia; Tacrolimus; Hypercalciuria; Calcineurin; Endocrinology; Internal medicine; Reabsorption; Calcium; Kidney; Diuretic; Pharmacology; Magnesium; Transplantation; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005720597,0.0008962469,0.001109806,0.0009409904,0.0003372745,0.0005295996,0.0007025958,0.001079948,0.00620357],"category_scores_gemma":[0.000293595,0.0004249101,0.0006021024,0.000488963,0.0007127064,0.0006874416,0.000277814,0.001635929,0.00237004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004801828,"about_ca_system_score_gemma":0.001020003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001383005,"about_ca_topic_score_gemma":0.002020189,"domain_scores_codex":[0.9990128,0.0001303214,0.0001183969,0.0001420517,0.0003110647,0.0002853578],"domain_scores_gemma":[0.9993042,0.00006649281,0.0002153736,0.0001025228,0.00009498748,0.0002164499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004518036,0.001279306,0.0002781165,0.000217181,0.00004316741,0.0002106491,0.00005418017,0.0001744342,0.9850213,0.0002550067,0.0007166571,0.007231981],"study_design_scores_gemma":[0.0006526446,0.01353625,0.006060247,0.00004871777,0.00008561985,0.0006808097,0.0001365068,0.001355965,0.9668548,0.0001330723,0.01042978,0.00002562134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794357,0.004250594,0.004574676,0.001073865,0.0004756138,0.0002690442,0.00223925,0.0009896411,0.006691609],"genre_scores_gemma":[0.952908,0.004920507,0.008010021,0.0004245698,0.0001820358,0.0007368056,0.00311545,0.0001245363,0.02957825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00620357,"threshold_uncertainty_score":0.02075297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03574818902515586,"score_gpt":0.3242965897717485,"score_spread":0.2885484007465926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}