{"id":"W4380448063","doi":"10.1093/ndt/gfad063d_3074","title":"#3074 CHANGES IN THE CLINICAL CHARACTERISTICS AND MANAGEMENT OF PATIENTS WITH AHUS OVER 10 YEARS: TRENDS FROM THE GLOBAL AHUS REGISTRY","year":2023,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Atypical hemolytic uremic syndrome; Eculizumab; Thrombotic microangiopathy; Pediatrics; Patient registry; Kidney disease; Dialysis; Internal medicine; Disease; Complement system; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003082891,0.0001167956,0.000249939,0.00006177985,0.00006009985,0.00001036681,0.000222509,0.0001189802,0.0002181748],"category_scores_gemma":[0.000009070494,0.00007407135,0.00005396536,0.0003078661,0.0002155084,0.00003201173,0.0000251758,0.00009465074,0.00002891737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001281408,"about_ca_system_score_gemma":0.000009685182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001464685,"about_ca_topic_score_gemma":0.001546137,"domain_scores_codex":[0.998665,0.0004986665,0.0003342829,0.0002482339,0.00007432957,0.0001794768],"domain_scores_gemma":[0.9990861,0.0004176581,0.0001826019,0.0002801329,0.00002329016,0.00001025155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001106777,0.0001384343,0.9834429,0.00003708923,0.0005224847,0.00002241849,0.0008179672,0.000003288869,0.00006021136,0.0001600315,0.001474456,0.01221394],"study_design_scores_gemma":[0.002291001,0.0001303559,0.9930915,0.00003237366,0.0006266515,0.000001703409,0.0001850132,0.00000470418,0.000008407233,0.00004904567,0.003506765,0.00007253914],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978729,0.0001461007,0.00001636809,0.0004516362,0.0001499852,0.000233052,0.001016957,0.00002553801,0.00008742543],"genre_scores_gemma":[0.99519,0.0006648109,0.00001097631,0.0003103915,0.00003441156,0.00006008361,0.003686489,0.000005733948,0.00003714089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0121414,"threshold_uncertainty_score":0.3020542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01895663225835446,"score_gpt":0.2825939498065582,"score_spread":0.2636373175482037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}