{"id":"W4380448063","doi":"10.1093/ndt/gfad063d_3074","title":"#3074 CHANGES IN THE CLINICAL CHARACTERISTICS AND MANAGEMENT OF PATIENTS WITH AHUS OVER 10 YEARS: TRENDS FROM THE GLOBAL AHUS REGISTRY","year":2023,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Atypical hemolytic uremic syndrome; Eculizumab; Thrombotic microangiopathy; Pediatrics; Patient registry; Kidney disease; Dialysis; Internal medicine; Disease; Complement system; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001787903,0.0002398178,0.0006017031,0.002550551,0.000310503,0.001036407,0.000536133,0.0004932609,0.004372586],"category_scores_gemma":[0.007551954,0.0002033857,0.0005211502,0.006517606,0.0003015907,0.001161256,0.0008038327,0.000650225,0.001504452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005165595,"about_ca_system_score_gemma":0.0009393552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005804315,"about_ca_topic_score_gemma":0.005875078,"domain_scores_codex":[0.9976739,0.0004823812,0.0006237079,0.0004901778,0.000464931,0.0002649767],"domain_scores_gemma":[0.9850633,0.001812633,0.009169267,0.0006139486,0.002254732,0.001086114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001609015,0.00002341619,0.977494,0.0001727229,0.00009376121,0.0001050392,0.0001380711,0.0001153733,0.0001499335,0.0001590078,0.009474096,0.01191374],"study_design_scores_gemma":[0.00001626229,0.00007051191,0.990411,0.0001797169,0.00004408254,0.0006675268,0.0003723842,0.0002501577,0.00009000035,0.00007170267,0.007810385,0.00001620568],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.893054,0.006529056,0.0008949445,0.003157083,0.000212571,0.00009503037,0.08497554,0.0002496623,0.01083214],"genre_scores_gemma":[0.9298565,0.003864523,0.00114691,0.001231211,0.0003000468,0.0002166013,0.06193963,0.0000800632,0.001364561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005804315,"threshold_uncertainty_score":0.01462781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01895663225835446,"score_gpt":0.2825939498065582,"score_spread":0.2636373175482037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}