{"id":"W4380449715","doi":"10.1101/2023.06.12.544645","title":"Targeting lipid nanoparticles to the blood brain barrier to ameliorate acute ischemic stroke","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"American Heart Association","keywords":"Nanocarriers; Penumbra; Blood–brain barrier; Pharmacology; Targeted drug delivery; Medicine; Drug delivery; Drug; Downregulation and upregulation; Dexamethasone; VCAM-1; Cell adhesion molecule; Chemistry; Ischemia; ICAM-1; Internal medicine; Immunology; Nanotechnology; Materials science; Central nervous system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007928935,0.0007275151,0.0006483803,0.0003339005,0.0007763707,0.0005490791,0.001235866,0.000319421,0.00005258585],"category_scores_gemma":[0.002682261,0.0005972011,0.0002006258,0.001514152,0.0001589485,0.0001618541,0.002069389,0.0009841925,0.000875625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009858735,"about_ca_system_score_gemma":0.0002964471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002852857,"about_ca_topic_score_gemma":0.000005684397,"domain_scores_codex":[0.9955291,0.0002657574,0.0006856154,0.001773028,0.0007126629,0.001033825],"domain_scores_gemma":[0.9968993,0.0003160717,0.000314299,0.00157765,0.0003356113,0.0005570551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004561203,0.0000238641,0.0007255996,0.00004864519,0.0001360981,0.00005589698,0.00009914615,0.0002929171,0.9680614,0.0001381666,0.03036976,0.000002872765],"study_design_scores_gemma":[0.0002468278,0.00007209907,0.003491405,0.00009864006,0.000171355,4.348063e-8,0.00001684024,0.00006649837,0.8991314,0.000001434142,0.09602267,0.0006807537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829422,0.0001865558,0.0009210206,0.007848289,0.004806668,0.001252298,0.00104496,0.0009794589,0.00001855934],"genre_scores_gemma":[0.9884769,0.0001142695,0.001350756,0.007503818,0.001494354,0.000628059,1.634971e-7,0.0001982647,0.0002334598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06892999,"threshold_uncertainty_score":0.9999023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02179971552451365,"score_gpt":0.2385620066131178,"score_spread":0.2167622910886041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}