{"id":"W4380480297","doi":"10.1038/s41467-023-38238-6","title":"Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; NHLBI Division of Intramural Research; Max and Minnie Tomerlin Voelcker Fund; National Institute on Drug Abuse; National Institute for Health and Care Research; National Institute on Aging; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs; University of California, San Diego; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Uniformed Services University of the Health Sciences; U.S. Air Force; National Key Research and Development Program of China; Ministero dell’Istruzione, dell’Università e della Ricerca; Wellcome Trust; National Natural Science Foundation of China; U.S. Department of Defense; European Commission; Bill and Melinda Gates Foundation; National Institute of General Medical Sciences; 59th Medical Wing; Henry M. Jackson Foundation; National Institutes of Health; U.S. Department of Health and Human Services; National Center for Advancing Translational Sciences; Elizabeth Glaser Pediatric AIDS Foundation","keywords":"Immunocompetence; Longevity; Immune system; Inflammation; Immunology; Immunity; Medicine; Sepsis; Stressor; Biology; Gerontology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003317084,0.0001947918,0.0002781702,0.0004421824,0.0002727583,0.0006099246,0.0001424463,0.0002394632,0.002246897],"category_scores_gemma":[0.0006914496,0.0001082993,0.0001278906,0.0002543549,0.0002670438,0.0003090126,0.000487875,0.0003793171,0.0003452316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001888038,"about_ca_system_score_gemma":0.0001513433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007562923,"about_ca_topic_score_gemma":0.001076338,"domain_scores_codex":[0.999872,0.00002583227,0.000007063504,0.00004573418,0.00002049635,0.00002888553],"domain_scores_gemma":[0.9996101,0.00003766648,0.0001783203,0.00003606639,0.0000555741,0.00008240159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001240167,0.0002817875,0.6313316,0.0002773598,0.0002603231,0.0002818973,0.000743519,0.0008150522,0.2861645,0.0008892047,0.00210022,0.07561438],"study_design_scores_gemma":[0.000006397142,0.0005090601,0.9847355,0.00005013397,0.00005399564,0.000399852,0.000407981,0.000558405,0.01078374,0.0006761045,0.001805151,0.00001378265],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963393,0.0008882612,0.0009077422,0.000124007,0.00001565453,0.000008671807,0.000449242,0.00003246302,0.001234645],"genre_scores_gemma":[0.9983003,0.0003153734,0.0006643453,0.00007579088,0.00001895763,0.00001307735,0.000154899,0.000004379211,0.000452959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002246897,"threshold_uncertainty_score":0.007516563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05813665887405838,"score_gpt":0.351870182385471,"score_spread":0.2937335235114126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}