{"id":"W4380536477","doi":"10.1002/smll.202302917","title":"Ionizable Lipid with Supramolecular Chemistry Features for RNA Delivery In Vivo","year":2023,"lang":"en","type":"article","venue":"Small","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick; Canada Research Chairs; University of Toronto","funders":"Temerty Faculty of Medicine, University of Toronto; Canadian Institutes of Health Research; Canada Research Chairs; Canada First Research Excellence Fund; University of Toronto; Natural Sciences and Engineering Research Council of Canada","keywords":"RNA; Small interfering RNA; In vivo; Rational design; Chemistry; Messenger RNA; Supramolecular chemistry; Biophysics; Dispersity; Lipid bilayer; Biochemistry; Nanotechnology; Biology; Materials science; Molecule; Membrane; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002042025,0.0004254459,0.0001501512,0.0001101031,0.0001105906,0.0002040469,0.0001603469,0.0002791824,0.0007439672],"category_scores_gemma":[0.0001015449,0.0001104685,0.0001870106,0.0001014721,0.0001769142,0.0002004814,0.0002432426,0.0002909623,0.0003474692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002767393,"about_ca_system_score_gemma":0.0002548079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002099752,"about_ca_topic_score_gemma":0.0002969166,"domain_scores_codex":[0.9999315,0.0000124761,0.000005844694,0.00001745263,0.00001806892,0.00001470548],"domain_scores_gemma":[0.9999485,0.00000724309,0.00002044158,0.000005069741,0.000008200971,0.00001058184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002494463,0.000008910216,0.00002551786,0.00002117142,0.000001966391,0.00001653911,0.000004514647,0.0001215788,0.9985668,0.0001183459,0.00002422489,0.00106539],"study_design_scores_gemma":[0.00001154844,0.0001067617,0.0001876406,0.000001865703,0.000006439086,0.00006611992,0.000003616425,0.0007122981,0.9970357,0.00004439221,0.001819568,0.000004071302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9212025,0.002584159,0.07011798,0.0003023293,0.00006951114,0.0001934741,0.000303981,0.0003910531,0.004834977],"genre_scores_gemma":[0.9712971,0.0009818642,0.02490986,0.0001454345,0.00001300787,0.0001283267,0.0001862747,0.00004614744,0.002291985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007439672,"threshold_uncertainty_score":0.002488792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01037758806189084,"score_gpt":0.2232150540543173,"score_spread":0.2128374659924265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}