{"id":"W4380536477","doi":"10.1002/smll.202302917","title":"Ionizable Lipid with Supramolecular Chemistry Features for RNA Delivery In Vivo","year":2023,"lang":"en","type":"article","venue":"Small","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick; Canada Research Chairs; University of Toronto","funders":"Temerty Faculty of Medicine, University of Toronto; Canadian Institutes of Health Research; Canada Research Chairs; Canada First Research Excellence Fund; University of Toronto; Natural Sciences and Engineering Research Council of Canada","keywords":"RNA; Small interfering RNA; In vivo; Rational design; Chemistry; Messenger RNA; Supramolecular chemistry; Biophysics; Dispersity; Lipid bilayer; Biochemistry; Nanotechnology; Biology; Materials science; Molecule; Membrane; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001007477,0.0001442193,0.0001207224,0.00003998019,0.00003874697,0.00002782894,0.0001969387,0.0001499146,0.00002971662],"category_scores_gemma":[0.00003493061,0.000130078,0.0000737501,0.0001461504,0.00003713379,0.000003049798,0.00007317389,0.00007615559,0.00001636849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001138624,"about_ca_system_score_gemma":0.00007896835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004862551,"about_ca_topic_score_gemma":0.0001678332,"domain_scores_codex":[0.9991435,0.00001362402,0.0001206937,0.0003415287,0.00007203202,0.0003086129],"domain_scores_gemma":[0.9995467,0.00001137684,0.00003537707,0.0002708209,0.00008050577,0.00005521811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002270737,0.0000298399,0.001106937,0.00004841986,0.0000382461,0.00001951946,0.00003628748,0.0004683152,0.9846183,0.000009472237,0.01277641,0.0006211858],"study_design_scores_gemma":[0.0006642313,0.0002441472,0.0007156561,0.00003645408,0.00001190698,0.00001283655,0.0001269937,0.0001189956,0.9666852,0.00003986046,0.03112826,0.0002154435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973002,0.0002707658,0.0003366608,0.0001479279,0.00007888052,0.0001780484,0.00003360901,0.00002641738,0.001627477],"genre_scores_gemma":[0.989598,0.0002409166,0.0005365327,0.0002944535,0.0002408465,0.00008939648,0.0002100427,0.00003172466,0.008758101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01835185,"threshold_uncertainty_score":0.5304425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01037758806189084,"score_gpt":0.2232150540543173,"score_spread":0.2128374659924265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}