{"id":"W4380550592","doi":"10.1002/adhm.202301033","title":"Enzyme‐Triggered Intestine‐Specific Targeting Adhesive Platform for Universal Oral Drug Delivery","year":2023,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"China Scholarship Council; Massachusetts Institute of Technology; Bill and Melinda Gates Foundation","keywords":"Drug delivery; Pharmacokinetics; Drug; Pharmacology; Dosing; Prodrug; Small intestine; Targeted drug delivery; Medicine; Gastrointestinal tract; Internal medicine; Materials science; Nanotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001630027,0.0005332342,0.0008778152,0.00031992,0.0007447231,0.00004691754,0.0004925265,0.0004117549,0.0004117213],"category_scores_gemma":[0.000345337,0.0005587396,0.0001604972,0.0006108154,0.0001756152,0.0005649432,0.0002111915,0.0005068182,0.0007929546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004940926,"about_ca_system_score_gemma":0.0002346199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001310229,"about_ca_topic_score_gemma":0.00007809917,"domain_scores_codex":[0.9956796,0.0005485264,0.00112573,0.0008671489,0.000258155,0.001520871],"domain_scores_gemma":[0.99633,0.001647602,0.0005827484,0.0004002239,0.0005676848,0.0004717159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004651058,0.0001364419,0.0006558017,0.001193623,0.000207717,0.0002277344,0.002969615,0.005248108,0.8860038,0.006460143,0.04638449,0.04586146],"study_design_scores_gemma":[0.00418634,0.0003164647,0.0001520085,0.0001719014,0.00006016671,0.00002975919,0.003938698,0.001081425,0.4956084,0.003585395,0.4900188,0.0008506835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815944,0.001588998,0.0006377194,0.001786788,0.00854037,0.002740627,0.001793178,0.001176055,0.000141874],"genre_scores_gemma":[0.9899994,0.001472678,0.003294994,0.001150462,0.0009776499,0.0004999345,0.001147104,0.0001466935,0.001311108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4436343,"threshold_uncertainty_score":0.999985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1385072278153807,"score_gpt":0.4273982253073731,"score_spread":0.2888909974919924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}