{"id":"W4380574630","doi":"10.20944/preprints202306.1022.v1","title":"An Integrated Multi-OMICS Approach Highlights Elevated Non-esterified Fatty Acids Impact BeWo Trophoblast Metabolism and Lipid Processing","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Birth, Development, and Health","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Victoria Hospital; London Health Sciences Centre; The Metabolomics Innovation Centre; Lawson Health Research Institute; University of Alberta; Western University","funders":"National Institutes of Health; Genome Canada","keywords":"Lipid metabolism; Gestational diabetes; Trophoblast; Offspring; Metabolomics; Endocrinology; Biology; Internal medicine; Placenta; Omics; NEFA; Beta oxidation; Metabolism; Biochemistry; Fatty acid; Fetus; Pregnancy; Medicine; Bioinformatics; Gestation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001489149,0.0009849787,0.001332006,0.002231195,0.0006995168,0.003009144,0.0004122126,0.0006095141,0.002190101],"category_scores_gemma":[0.001296716,0.0003270656,0.001514001,0.002333335,0.0003396751,0.0008858544,0.001400985,0.001093434,0.000701529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006128054,"about_ca_system_score_gemma":0.001341305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002730118,"about_ca_topic_score_gemma":0.004292353,"domain_scores_codex":[0.9992366,0.0001782562,0.00005334752,0.0002600044,0.0001820794,0.00008966173],"domain_scores_gemma":[0.999495,0.0001771163,0.00007140111,0.0000851724,0.0001253766,0.0000459379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001497031,0.0002576494,0.09111355,0.005723333,0.002961558,0.001182807,0.001233854,0.008414336,0.7197384,0.006180354,0.009287296,0.1524098],"study_design_scores_gemma":[0.0001444518,0.000898591,0.5107301,0.001664243,0.004451458,0.00199188,0.003518713,0.05125243,0.1787136,0.04657182,0.1996476,0.0004150707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6101519,0.04267209,0.1955286,0.005641002,0.0009740445,0.0004906391,0.1212966,0.003411399,0.01983377],"genre_scores_gemma":[0.6870636,0.02612596,0.2060893,0.003156882,0.0003881774,0.000739178,0.0682792,0.0008904827,0.007267108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003009144,"threshold_uncertainty_score":0.007875443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1266421956139626,"score_gpt":0.373628602831581,"score_spread":0.2469864072176184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}