{"id":"W4380576571","doi":"10.1038/s41467-023-39233-7","title":"A single-domain green fluorescent protein catenane","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"Beijing National Laboratory for Molecular Sciences; National Natural Science Foundation of China","keywords":"Catenane; Green fluorescent protein; Fluorescence; Biophysics; Fluorescent protein; Protein engineering; Fusion protein; Chemistry; Protein domain; Macromolecule; Computational biology; Biology; Biochemistry; Physics; Gene; Molecule; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002246752,0.0002245927,0.0001818844,0.0001462242,0.0001730128,0.0003071565,0.0002404328,0.00044479,0.0009374504],"category_scores_gemma":[0.0001829581,0.0001021047,0.0002182379,0.0001370948,0.000230226,0.000413366,0.0002541254,0.0005286373,0.0003553329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002847543,"about_ca_system_score_gemma":0.0002601391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001992186,"about_ca_topic_score_gemma":0.0002747144,"domain_scores_codex":[0.9998802,0.00001384732,0.000007033756,0.00004967081,0.00002896682,0.00002026447],"domain_scores_gemma":[0.9998907,0.00001597516,0.00002204312,0.00001417605,0.00001859306,0.00003848185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002463127,0.00001892885,0.00009259539,0.00004535701,0.000002856505,0.00004348787,0.00001863988,0.0002308893,0.9963469,0.0007873881,0.00004414276,0.00234423],"study_design_scores_gemma":[0.00000687519,0.0001962217,0.000272897,0.000004169353,0.00000394243,0.0001900167,0.00001246404,0.0008598891,0.9932775,0.00008446122,0.005084411,0.000007144268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9479496,0.001651363,0.0439466,0.000351835,0.0001064255,0.0001460284,0.000355346,0.0001974376,0.005295362],"genre_scores_gemma":[0.9598386,0.0007928925,0.03253046,0.0001057562,0.000007692284,0.00008245777,0.0004123619,0.0000264246,0.006203495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009374504,"threshold_uncertainty_score":0.003136098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607881278319032,"score_gpt":0.2603077135262227,"score_spread":0.2442289007430324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}