{"id":"W4380576571","doi":"10.1038/s41467-023-39233-7","title":"A single-domain green fluorescent protein catenane","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"Beijing National Laboratory for Molecular Sciences; National Natural Science Foundation of China","keywords":"Catenane; Green fluorescent protein; Fluorescence; Biophysics; Fluorescent protein; Protein engineering; Fusion protein; Chemistry; Protein domain; Macromolecule; Computational biology; Biology; Biochemistry; Physics; Gene; Molecule; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007241736,0.00009436197,0.00007106304,0.00003615846,0.0001307331,0.00001762809,0.000537098,0.000278641,0.000005930403],"category_scores_gemma":[0.00007081386,0.00008114509,0.00005124379,0.0002635893,0.00008373537,0.000003246755,0.0003493026,0.000260321,0.00002543011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001339349,"about_ca_system_score_gemma":0.00002084644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009769433,"about_ca_topic_score_gemma":0.00006492129,"domain_scores_codex":[0.9994005,0.00005635547,0.0001283059,0.0001732961,0.0000888954,0.0001526695],"domain_scores_gemma":[0.9989355,0.000007956673,0.00004891696,0.0008691162,0.00008509696,0.0000534114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001250981,0.00002511346,0.0002760135,0.000006794169,0.00001226038,4.279263e-7,0.00002623149,2.361404e-7,0.9948496,0.0007807271,0.002094307,0.001915819],"study_design_scores_gemma":[0.000250758,0.00006917299,0.009242002,0.00001870792,0.000008050447,0.000008257884,0.00003384676,0.00006816732,0.6724998,0.000742122,0.3168503,0.0002087771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886718,0.0008117756,0.00003787167,0.009282681,0.00007313027,0.0002648366,0.00005285331,0.00007743804,0.000727628],"genre_scores_gemma":[0.9947031,0.0001134488,0.001372032,0.0003216306,0.0001124543,0.00005028642,0.002584225,0.00001474175,0.0007280848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3223497,"threshold_uncertainty_score":0.3309001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607881278319032,"score_gpt":0.2603077135262227,"score_spread":0.2442289007430324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}