{"id":"W4380577757","doi":"10.1002/pro.4705","title":"Orthogonal translation with 5‐cyanotryptophan as an infrared probe for local structural information, electrostatics, and hydrogen bonding","year":2023,"lang":"en","type":"article","venue":"Protein Science","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Technische Universität Berlin; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Einstein Stiftung Berlin; Deutsche Forschungsgemeinschaft","keywords":"Electrostatics; Context (archaeology); Hydrogen bond; Rational design; Chemistry; Translation (biology); Materials science; Chemical physics; Nanotechnology; Biology; Biochemistry; Molecule; Organic chemistry; Physical chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004408722,0.0001102901,0.00007880761,0.00008184624,0.0003012701,0.0001053523,0.000175241,0.00005825671,0.000005193909],"category_scores_gemma":[0.0001090255,0.00009081931,0.00001829638,0.0002787783,0.0002637352,0.00008894595,0.00003319954,0.00003681679,0.000006935034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001085302,"about_ca_system_score_gemma":0.0002164413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006352649,"about_ca_topic_score_gemma":0.000006963156,"domain_scores_codex":[0.9990425,0.00002127852,0.0001513912,0.0002552022,0.0002421551,0.0002875011],"domain_scores_gemma":[0.9994977,0.000007876372,0.00007325256,0.0001566138,0.0001660653,0.00009853028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001422361,0.000003158322,0.0001161464,0.00002803441,0.00000508318,3.258659e-7,0.0002183896,0.00004405655,0.9721176,0.004045981,0.00000426726,0.02327472],"study_design_scores_gemma":[0.0003875598,0.0008287947,0.0002513021,0.00001636557,0.000004763087,0.00001247781,0.0001145906,0.004882764,0.9827955,0.008097121,0.00243264,0.0001761652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.92164,0.00003525682,0.07703149,0.00009474441,0.00002371572,0.0009716127,0.00001701549,0.00003222197,0.0001539481],"genre_scores_gemma":[0.9754701,0.000003671538,0.02393147,0.00007071639,0.00004476669,0.0002052356,0.00009182253,0.000009896276,0.0001723203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05383011,"threshold_uncertainty_score":0.3703504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01047514113486044,"score_gpt":0.258748614682324,"score_spread":0.2482734735474636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}