{"id":"W4380605918","doi":"10.1126/sciadv.adf8332","title":"In vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscape","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McGill University; Montreal Neurological Institute and Hospital","funders":"NIHR Cambridge Biomedical Research Centre; Engineering and Physical Sciences Research Council; Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Gates Cambridge Trust; Science and Technology Facilities Council; Royal College of Anaesthetists; Cambridge Commonwealth Trust; Fonds De La Recherche Scientifique - FNRS; Imperial College London; Canada Research Chairs; Mind Science Foundation; Université de Liège; Canada Excellence Research Chairs, Government of Canada; Alexander Mosley Charitable Trust; European Commission; Heffter Research Institute; National Institute for Health and Care Research; Cambridge Trust; Wellcome Trust; University of California, San Francisco; James S. McDonnell Foundation; Canadian Institute for Advanced Research; European Space Agency","keywords":"Neuroscience; Neurotransmitter receptor; Neurotransmitter; Human brain; Pharmacology; Psychology; Medicine; Central nervous system; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033903,0.0001002407,0.00009358495,0.0002587141,0.0001326667,0.0001862478,0.00009481801,0.0001648162,0.00155366],"category_scores_gemma":[0.0001845045,0.0001206599,0.00007825067,0.0001389006,0.0002891849,0.000169902,0.0001323646,0.0002499026,0.000151471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001158415,"about_ca_system_score_gemma":0.0001259178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001136285,"about_ca_topic_score_gemma":0.002582072,"domain_scores_codex":[0.9999686,0.000007178416,0.000001465883,0.00001048659,0.000005927711,0.000006248128],"domain_scores_gemma":[0.9999484,0.00001646834,0.00001269092,0.000008047658,0.000006722916,0.000007787459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002629657,0.00004086729,0.003380216,0.00004812979,0.00003269037,0.00008690115,0.00006983036,0.0003855899,0.9838322,0.0002270625,0.0001911699,0.01144237],"study_design_scores_gemma":[0.00005858098,0.000971102,0.6154324,0.00002873671,0.0001190217,0.001749253,0.0004220009,0.008286583,0.3680276,0.001610402,0.003266318,0.00002804753],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821879,0.001271121,0.01406206,0.0001251347,0.0000174281,0.00002426647,0.0003132399,0.00006918216,0.0019296],"genre_scores_gemma":[0.9934503,0.0009372094,0.004505664,0.0000702957,0.00001105103,0.00004030879,0.0001894483,0.00002397772,0.0007718029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00155366,"threshold_uncertainty_score":0.005197465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06252226508792122,"score_gpt":0.3729836125985843,"score_spread":0.3104613475106631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}