{"id":"W4380624299","doi":"10.1101/2023.06.13.544658","title":"H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institutes of Health; Ian's Friends Foundation; ChadTough Foundation; University of Michigan; Pediatric Brain Tumor Foundation; American Brain Tumor Association","keywords":"Reprogramming; Epigenetics; Mutation; Gene; Immune system; Biology; Genetics; Cancer research; Genetic enhancement; Medicine; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007819614,0.0001706538,0.0001811674,0.0001232013,0.00006639436,0.0001457219,0.0001308818,0.0001710459,0.0009923682],"category_scores_gemma":[0.00005553244,0.0000535342,0.0001374564,0.00007168813,0.0001544008,0.0000978536,0.0001233892,0.0003180302,0.0001385567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001129032,"about_ca_system_score_gemma":0.0001146667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005041526,"about_ca_topic_score_gemma":0.0008670932,"domain_scores_codex":[0.9999424,0.00000732102,0.000003915921,0.00001237238,0.00001504369,0.00001887219],"domain_scores_gemma":[0.9999759,0.000003204472,0.000007673937,0.000003647298,0.000001937812,0.000007679882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002187509,0.00009459278,0.0002767344,0.00002842163,0.000007228301,0.00006493899,0.00001473727,0.0001446495,0.994189,0.00008846024,0.00006075175,0.004811721],"study_design_scores_gemma":[0.00008279852,0.002747864,0.008593679,0.000006708659,0.00004927603,0.0005750868,0.00005346557,0.001420819,0.9837803,0.00008792448,0.002595634,0.000006528097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997707,0.0004515253,0.0008616245,0.00003903828,0.00001519922,0.00002084784,0.0001140972,0.00004810935,0.0007425345],"genre_scores_gemma":[0.9987819,0.0002251605,0.0003403725,0.00002307729,0.000003546859,0.00001136013,0.00008274002,0.000006508764,0.0005253491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009923682,"threshold_uncertainty_score":0.00331974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0204746725218669,"score_gpt":0.263331616058379,"score_spread":0.242856943536512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}