{"id":"W4380625140","doi":"10.21203/rs.3.rs-3002842/v1","title":"Autoinflammatory Gene Mutations Associated with Eosinophilia and Asthma","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Familial Mediterranean fever; Medicine; Eosinophilia; MEFV; Hypereosinophilia; Asthma; Pyrin domain; Eosinophilic; Immunology; Gene mutation; Dermatology; Pediatrics; Internal medicine; Inflammasome; Pathology; Mutation; Disease; Gene; Genetics; Inflammation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166534,0.0004024841,0.0002577441,0.0006435561,0.0004945243,0.0004979036,0.0002350939,0.0008236513,0.005033541],"category_scores_gemma":[0.0007510594,0.0001435364,0.0001804876,0.0004072375,0.0004575276,0.000180143,0.0004007167,0.000414406,0.0006013534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004014393,"about_ca_system_score_gemma":0.0002936292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003244978,"about_ca_topic_score_gemma":0.003399302,"domain_scores_codex":[0.9998201,0.00001858165,0.00002340425,0.00003889434,0.0000470951,0.00005205794],"domain_scores_gemma":[0.999627,0.0001005876,0.00009768448,0.00002583469,0.00004111888,0.0001077135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.0002502034,0.00007759421,0.252377,0.00009151163,0.00005786513,0.7153293,0.0005954023,0.0001895655,0.01826187,0.0005713837,0.002371324,0.009826829],"study_design_scores_gemma":[0.00005470333,0.0001214603,0.2855676,0.0000437999,0.00005133396,0.702967,0.0003307874,0.0004454142,0.006380513,0.0003290812,0.003694338,0.00001388243],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991964,0.0009324936,0.000309187,0.0003361167,0.00004947958,0.00003073165,0.0002744595,0.0000312285,0.006072321],"genre_scores_gemma":[0.9986207,0.0001562557,0.0001684898,0.0001009123,0.00003639392,0.00000289216,0.0001032431,0.000006659416,0.0008044001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005033541,"threshold_uncertainty_score":0.01683891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0329003351571449,"score_gpt":0.3316953718292755,"score_spread":0.2987950366721306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}