{"id":"W4380625655","doi":"10.1093/ndt/gfad063a_4328","title":"#4328 CHK-336, A FIRST-IN-CLASS ORALLY ADMINISTERED LDH INHIBITOR: SAFETY, PK AND TARGET ENGAGEMENT IN A FIRST-IN-HUMAN PHASE 1 HEALTHY VOLUNTEER STUDY","year":2023,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Kidney Stones and Urolithiasis Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Pharmacokinetics; Pharmacology; Oxalate; Urine; Urinalysis; Lactate dehydrogenase; Placebo; Kidney; Internal medicine; Chemistry; Biochemistry; Enzyme; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00206093,0.001362573,0.001388409,0.0002822216,0.0005796308,0.0007683859,0.0005375991,0.001206935,0.005114702],"category_scores_gemma":[0.0008797282,0.0005974145,0.000694419,0.0002259916,0.0009002759,0.0006397482,0.0002782174,0.002151224,0.00104841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005026311,"about_ca_system_score_gemma":0.001646277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007347587,"about_ca_topic_score_gemma":0.001622393,"domain_scores_codex":[0.9993293,0.0003415719,0.00002746455,0.0001122004,0.00008095037,0.0001083508],"domain_scores_gemma":[0.9992673,0.0001012212,0.0001320736,0.0000858238,0.00009379585,0.0003198326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5816121,0.0835606,0.006501779,0.001144127,0.000793417,0.0004848923,0.0003883939,0.001008282,0.241663,0.0004245717,0.007642367,0.07477657],"study_design_scores_gemma":[0.1009657,0.8640464,0.0110496,0.00002864104,0.0002928382,0.0003121897,0.00008849296,0.000693768,0.01659324,0.0001464889,0.005748066,0.00003461009],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877049,0.00116908,0.00184684,0.0003963533,0.000177718,0.005236406,0.001774358,0.0001958916,0.001498466],"genre_scores_gemma":[0.9801237,0.001121716,0.003545137,0.000852911,0.0002330591,0.00431516,0.001778518,0.00006052653,0.007969199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005114702,"threshold_uncertainty_score":0.01711041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0260365856234354,"score_gpt":0.323659889236731,"score_spread":0.2976233036132956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}