{"id":"W4380626090","doi":"10.1093/ndt/gfad063a_3848","title":"#3848 ORIGIN TRIAL: 24-WK PRIMARY ANALYSIS OF A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PH2B STUDY OF ATACICEPT IN PATIENTS WITH IGAN","year":2023,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Placebo; Internal medicine; Proteinuria; Gastroenterology; Renal function; Nephropathy; Population; Immunology; Endocrinology; Diabetes mellitus; Kidney; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003475694,0.002123141,0.005062433,0.0005045307,0.000724785,0.001561499,0.001122709,0.001981145,0.01102022],"category_scores_gemma":[0.002273213,0.0009187901,0.002689131,0.0004346218,0.001257442,0.001640686,0.0005736344,0.003178343,0.001940704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008727895,"about_ca_system_score_gemma":0.001282849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009715673,"about_ca_topic_score_gemma":0.001702568,"domain_scores_codex":[0.9986069,0.0007820812,0.00007562698,0.000294571,0.00009019517,0.0001506997],"domain_scores_gemma":[0.9984352,0.0003485598,0.0003765023,0.0001658046,0.0001763058,0.0004976427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9862894,0.002765245,0.0003846473,0.0006535301,0.001332487,0.00002344179,0.00002370989,0.0001336023,0.00134642,0.00005671652,0.0008736922,0.006117081],"study_design_scores_gemma":[0.9731416,0.02464745,0.00105159,0.00002004441,0.0004164597,0.00001724482,0.000008464112,0.0001485442,0.0001055951,0.0000624661,0.0003709868,0.000009549651],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517854,0.01961968,0.00223145,0.00161699,0.001687316,0.01173952,0.005490275,0.0005037619,0.005325715],"genre_scores_gemma":[0.9720849,0.004149065,0.002542056,0.002266326,0.001128192,0.009259039,0.002528993,0.00007696418,0.00596427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01102022,"threshold_uncertainty_score":0.03686631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01761153777316911,"score_gpt":0.2855754329529114,"score_spread":0.2679638951797423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}