{"id":"W4380626304","doi":"10.1093/ndt/gfad063a_3280","title":"#3280 B-CELL RECOVERY IN A RANDOMIZED CONTROLLED TRIAL OF B-CELL DEPLETION WITH OBINUTUZUMAB FOR THE TREATMENT OF PROLIFERATIVE LUPUS NEPHRITIS (NOBILITY)","year":2023,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Obinutuzumab; Medicine; Lupus nephritis; Immunology; B cell; Belimumab; CD19; Internal medicine; Rituximab; Pharmacology; Gastroenterology; Flow cytometry; Antibody; B-cell activating factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002014674,0.001050698,0.002520333,0.0003016281,0.0004385041,0.001097651,0.0006936871,0.001164332,0.005355277],"category_scores_gemma":[0.001974088,0.0004816196,0.001605391,0.0003097293,0.0008139943,0.0007606572,0.0003618792,0.002027429,0.0005061303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006438869,"about_ca_system_score_gemma":0.00102195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00086199,"about_ca_topic_score_gemma":0.00251557,"domain_scores_codex":[0.9989567,0.0006494846,0.00006731976,0.0001517267,0.00006369337,0.000111122],"domain_scores_gemma":[0.9989091,0.0003148978,0.000311483,0.0000687397,0.00007509016,0.000320574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9884396,0.002600202,0.0007376124,0.0004938376,0.0008476178,0.00002337573,0.00002298897,0.00006412048,0.0009432875,0.00004966362,0.0003025816,0.005475281],"study_design_scores_gemma":[0.9425697,0.05319082,0.002595211,0.00004653849,0.0006284558,0.00001936653,0.0000175172,0.0002206057,0.0001766745,0.00009382449,0.0004313005,0.0000101089],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868885,0.005722576,0.0004194037,0.0006483171,0.0008297814,0.003454952,0.0006248855,0.00006922732,0.00134221],"genre_scores_gemma":[0.9912964,0.001592847,0.0007323622,0.0007746785,0.0004550852,0.003008767,0.0004060937,0.000009292684,0.001724493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005355277,"threshold_uncertainty_score":0.01791513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01588234983597459,"score_gpt":0.2770401285181304,"score_spread":0.2611577786821558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}