{"id":"W4380633214","doi":"10.3389/fcell.2023.1178316","title":"Cervical cancer benefits from trabectedin combination with the β-blocker propranolol: in vitro and ex vivo evaluations in patient-derived organoids","year":2023,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"PharmaMar; Regione Puglia","keywords":"Ex vivo; Trabectedin; Medicine; In vivo; Organoid; Cancer; Cervical cancer; Propranolol; Pharmacology; Oncology; Internal medicine; Biology; Pathology; Neuroscience; Sarcoma; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003338022,0.0003205426,0.0004002097,0.0002698486,0.0001622952,0.0002564149,0.0001653501,0.0002516341,0.001099709],"category_scores_gemma":[0.0001908601,0.0001224374,0.0005079313,0.000226788,0.0002339961,0.0002915615,0.0001562015,0.0005580798,0.0002129777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002479678,"about_ca_system_score_gemma":0.000244295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006341825,"about_ca_topic_score_gemma":0.001104377,"domain_scores_codex":[0.9998407,0.00004850883,0.00001320403,0.00002793657,0.00003726104,0.00003228588],"domain_scores_gemma":[0.9998484,0.00004726391,0.00002763827,0.00002483747,0.00001267521,0.0000391666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001270245,0.0005354087,0.0008565388,0.0001401622,0.0000379284,0.0002642354,0.0001409887,0.000479128,0.9907582,0.00007195082,0.0002167428,0.005228494],"study_design_scores_gemma":[0.0001626309,0.0135221,0.01329293,0.00001965433,0.0001859817,0.0008698911,0.0001985831,0.001999859,0.9654201,0.00005983149,0.004252905,0.00001544729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952545,0.002466339,0.0009335707,0.00008787428,0.00003566603,0.00005531991,0.0003778078,0.00003401608,0.0007548979],"genre_scores_gemma":[0.996622,0.001214324,0.001032912,0.00003850077,0.00001429747,0.00006306702,0.0004574712,0.00001047208,0.0005469669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001099709,"threshold_uncertainty_score":0.003678858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102706898077238,"score_gpt":0.2377018235392459,"score_spread":0.2266747545584736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}