{"id":"W4380680304","doi":"10.1161/circ.146.suppl_1.11484","title":"Abstract 11484: Upregulation of Dynamin 2 Increases Mitochondrial Fission and Cell Proliferation in Pulmonary Arterial Hypertension","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Mitochondrial fission; DNM1L; Apoptosis; Cell cycle; Mitosis; Cell growth; Mitochondrion; Cell biology; Medicine; Biology; Pathology; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001311444,0.0002970633,0.0004374878,0.0002718582,0.0002439779,0.0002832645,0.000166744,0.0004215926,0.003741137],"category_scores_gemma":[0.0000976502,0.0001580578,0.000291688,0.000231279,0.0002335098,0.0002467162,0.0002124482,0.0009179678,0.0006121522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002573814,"about_ca_system_score_gemma":0.0002483151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002868809,"about_ca_topic_score_gemma":0.0004342216,"domain_scores_codex":[0.9998944,0.00001286187,0.0000123082,0.00002588141,0.00003457895,0.00001999298],"domain_scores_gemma":[0.9999282,0.00001007812,0.00002076226,0.000004979269,0.000009348426,0.00002666593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006904455,0.0001254709,0.0003050122,0.0002427851,0.00001568375,0.00009796457,0.00002183941,0.000041274,0.9942905,0.0001202027,0.0004812007,0.003567774],"study_design_scores_gemma":[0.0003056733,0.00193526,0.01510286,0.00003442703,0.0000832303,0.00079579,0.00007055538,0.0009665567,0.968483,0.0001229677,0.0120858,0.00001383445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824232,0.007182305,0.002938339,0.0008345205,0.0004386272,0.00009476873,0.001615195,0.0003135487,0.004159585],"genre_scores_gemma":[0.9825245,0.00355484,0.002456655,0.0002893401,0.0001274008,0.0002481302,0.001520145,0.00003538022,0.009243734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003741137,"threshold_uncertainty_score":0.01251537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009507650437610269,"score_gpt":0.2155972145357783,"score_spread":0.206089564098168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}