{"id":"W4380680885","doi":"10.1111/hiv.13520","title":"Treatment‐emergent reverse transcriptase resistance during antiretroviral therapy with bictegravir, tenofovir alafenamide, and emtricitabine: A case series","year":2023,"lang":"en","type":"article","venue":"HIV Medicine","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; AIDS Vancouver; Vancouver Infectious Diseases Centre; University of British Columbia; St. Michael's Hospital","funders":"Canada Research Chairs","keywords":"Emtricitabine; Medicine; Tenofovir alafenamide; Virology; Drug resistance; Abacavir; Viral quasispecies; Resistance mutation; Reverse transcriptase; Internal medicine; Viral load; Oncology; Human immunodeficiency virus (HIV); Genetics; Virus; Antiretroviral therapy; Biology; Polymerase chain reaction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006185625,0.002474651,0.001317657,0.002192638,0.003629419,0.00199568,0.001524616,0.004783707,0.002318948],"category_scores_gemma":[0.004007679,0.001372464,0.001695157,0.001781724,0.002031468,0.002237017,0.001861165,0.003785815,0.0007588938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001581313,"about_ca_system_score_gemma":0.001171412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004672198,"about_ca_topic_score_gemma":0.004711775,"domain_scores_codex":[0.9986093,0.0001874225,0.0001974049,0.0003330507,0.0002307989,0.0004420278],"domain_scores_gemma":[0.9972364,0.0007836045,0.0007072971,0.0001854993,0.0001916952,0.0008954274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00002824488,0.00006064569,0.01171721,0.00003314147,0.00001882439,0.9853697,0.0003777168,0.00008239755,0.0003433763,0.0001194563,0.000406351,0.001443024],"study_design_scores_gemma":[0.000008472118,0.000040383,0.003298961,0.00002876464,0.00001856322,0.9956056,0.0002257669,0.0002136937,0.000152331,0.00008247414,0.000313443,0.00001146925],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780616,0.006502379,0.003909186,0.002656989,0.0004298179,0.0002837132,0.000189017,0.0001222202,0.007845229],"genre_scores_gemma":[0.9952292,0.001593535,0.001000897,0.0007306707,0.0005715951,0.00003536834,0.00008049026,0.00003112132,0.0007269869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004783707,"threshold_uncertainty_score":0.0114733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01852969808060011,"score_gpt":0.2531929371088467,"score_spread":0.2346632390282466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}