{"id":"W4380680885","doi":"10.1111/hiv.13520","title":"Treatment‐emergent reverse transcriptase resistance during antiretroviral therapy with bictegravir, tenofovir alafenamide, and emtricitabine: A case series","year":2023,"lang":"en","type":"article","venue":"HIV Medicine","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; AIDS Vancouver; Vancouver Infectious Diseases Centre; University of British Columbia; St. Michael's Hospital","funders":"Canada Research Chairs","keywords":"Emtricitabine; Medicine; Tenofovir alafenamide; Virology; Drug resistance; Abacavir; Viral quasispecies; Resistance mutation; Reverse transcriptase; Internal medicine; Viral load; Oncology; Human immunodeficiency virus (HIV); Genetics; Virus; Antiretroviral therapy; Biology; Polymerase chain reaction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001475376,0.0004818184,0.0007139986,0.000461608,0.0003133921,0.00001491337,0.00005959531,0.00008544373,0.0001910045],"category_scores_gemma":[0.00004100553,0.0002858826,0.0000831824,0.00106686,0.0002975132,0.0001628834,0.00001752532,0.0001487837,0.00005144085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002011751,"about_ca_system_score_gemma":0.0001736576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001309133,"about_ca_topic_score_gemma":0.0001797801,"domain_scores_codex":[0.9979303,0.0000594117,0.0004353537,0.0005841605,0.0004424034,0.000548369],"domain_scores_gemma":[0.9989621,0.00005963995,0.00009852547,0.0004291167,0.00008408034,0.0003665198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01635184,0.001417354,0.5313435,0.00114717,0.002835806,0.2994078,0.02981165,0.000004818553,0.04089153,0.0007603138,0.05835395,0.01767429],"study_design_scores_gemma":[0.1941178,0.01889813,0.2198734,0.004254681,0.004393423,0.05876301,0.03855581,0.00025875,0.02246343,0.0003400657,0.4347887,0.003292814],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720286,0.003144877,0.00001230134,0.02177226,0.0001364018,0.0009569281,0.00006136267,0.0003381679,0.001549059],"genre_scores_gemma":[0.7885886,0.008026121,0.0009477501,0.0001862313,0.0002273394,0.0001644701,0.0003296903,0.00008059506,0.2014492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3764347,"threshold_uncertainty_score":0.9999593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01852969808060011,"score_gpt":0.2531929371088467,"score_spread":0.2346632390282466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}