{"id":"W4380685105","doi":"10.1172/jci168553","title":"Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues","year":2023,"lang":"en","type":"review","venue":"Journal of Clinical Investigation","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging","keywords":"Disease; Tau pathology; Clinical trial; Tauopathy; Mechanism (biology); Tau protein; Neuroscience; Medicine; Drug development; Neurodegeneration; Bioinformatics; Psychology; Drug; Alzheimer's disease; Biology; Pathology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001082875,0.001225899,0.001926803,0.003216348,0.0004124036,0.001470286,0.001072195,0.001565671,0.003712358],"category_scores_gemma":[0.001187903,0.0003000494,0.0006827989,0.002941035,0.0008329962,0.002286812,0.0008691699,0.002974651,0.002178205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001014943,"about_ca_system_score_gemma":0.001629919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001257348,"about_ca_topic_score_gemma":0.002412377,"domain_scores_codex":[0.9996831,0.00007189371,0.0000500479,0.0000454754,0.0001199478,0.00002942139],"domain_scores_gemma":[0.9995167,0.0002471648,0.00006339308,0.00001624561,0.0001146924,0.00004176487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001138446,0.0001024195,0.0001200139,0.02721898,0.0001008709,0.0001735905,0.0001075001,0.0004076676,0.001221635,0.006578233,0.04711667,0.9167386],"study_design_scores_gemma":[0.00003075148,0.000123044,0.0006642456,0.0126783,0.0001342126,0.00113113,0.00009337089,0.00008708761,0.0002612104,0.0053907,0.979386,0.0000199065],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003072572,0.9991106,0.00003447352,0.0002023549,0.0001507865,0.0000028466,0.000005779637,0.000003838586,0.0004585768],"genre_scores_gemma":[0.0002338976,0.9990184,0.00008488387,0.000198741,0.0001375202,0.000004681328,0.000009528858,8.685226e-7,0.0003115209],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003712358,"threshold_uncertainty_score":0.01241904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2805028530238305,"score_gpt":0.4913206773068054,"score_spread":0.2108178242829749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}