{"id":"W4380685568","doi":"10.1021/acs.jmedchem.3c00633","title":"Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant <i>Enterococcus</i>","year":2023,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Glycopeptide; Vancomycin; Chemistry; Antibiotics; Glycopeptide antibiotic; Enterococcus; Microbiology; Biochemistry; Bacteria; Biology; Staphylococcus aureus; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460324,0.0002358314,0.00008067207,0.0001279164,0.0000640875,0.0001726448,0.0001549264,0.0001478101,0.002697781],"category_scores_gemma":[0.0001289194,0.0001033228,0.0001236664,0.0001028872,0.00009768447,0.0002097327,0.0001500291,0.0004005423,0.000811574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001213594,"about_ca_system_score_gemma":0.0001560499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001460322,"about_ca_topic_score_gemma":0.0002720859,"domain_scores_codex":[0.9999464,0.00001309112,0.000004189924,0.00001012827,0.00001626248,0.00001007337],"domain_scores_gemma":[0.9999422,0.00001047646,0.00002352236,0.000008123205,0.000006917131,0.000008823762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004872512,0.0000166719,0.00004402913,0.00003052017,0.000001891196,0.00005290656,0.000006630323,0.0001996657,0.996027,0.0003931194,0.0001461552,0.003032721],"study_design_scores_gemma":[0.00002410461,0.0004837595,0.0008442542,0.00001032408,0.000005109489,0.0002698499,0.00001097937,0.00151784,0.9844194,0.0001815872,0.01222584,0.00000690867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8816897,0.002236382,0.08884196,0.00056539,0.0001513347,0.0002739869,0.001619009,0.0007678426,0.0238543],"genre_scores_gemma":[0.9261935,0.002606492,0.06215826,0.0001760411,0.00002736757,0.000121866,0.001354055,0.00010435,0.00725804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002697781,"threshold_uncertainty_score":0.009025037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.018721226874348,"score_gpt":0.2600019802963197,"score_spread":0.2412807534219717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}