{"id":"W4380730007","doi":"10.1080/14756366.2023.2220084","title":"Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope","year":2023,"lang":"en","type":"review","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Qatar National Library","keywords":"Prodrug; Drug; Cancer; Prostate cancer; Pharmacology; Multiple myeloma; Boronic acid; Medicine; Chemistry; Cancer drugs; Combinatorial chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006419855,0.000649057,0.001240104,0.001265594,0.0002321313,0.0009354224,0.0006685475,0.001075667,0.003171118],"category_scores_gemma":[0.0004193748,0.0003691202,0.0004896834,0.001385365,0.0004822701,0.001477693,0.0004750295,0.002033898,0.001558021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004749065,"about_ca_system_score_gemma":0.0007476941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006782043,"about_ca_topic_score_gemma":0.001933905,"domain_scores_codex":[0.9998525,0.00002563947,0.00001562839,0.0000246871,0.00005322003,0.00002821176],"domain_scores_gemma":[0.9998443,0.0000622608,0.00002815409,0.000005839839,0.00004141234,0.00001804025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001421338,0.0001636643,0.0001299406,0.01967525,0.00009944952,0.0002726985,0.0001049924,0.001022232,0.009991043,0.01406516,0.02629157,0.9280419],"study_design_scores_gemma":[0.00004362586,0.00026833,0.0004054049,0.002623422,0.00008723912,0.0007308591,0.00008098194,0.0002542337,0.002104403,0.003264928,0.9901133,0.00002325548],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00039694,0.9979582,0.0002353365,0.0002617812,0.0001363802,0.000006370624,0.0000184573,0.000008173329,0.0009783077],"genre_scores_gemma":[0.001865886,0.9964977,0.0003628776,0.0002676202,0.00009884541,0.00001109383,0.00002466871,0.000001917934,0.0008694176],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003171118,"threshold_uncertainty_score":0.01060843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220933488969143,"score_gpt":0.3444090392587072,"score_spread":0.3221997043690157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}