{"id":"W4380730049","doi":"10.1161/jaha.122.022352","title":"Loss of PI3Kα Mediates Protection From Myocardial Ischemia–Reperfusion Injury Linked to Preserved Mitochondrial Function","year":2023,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian VIGOUR Centre; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Reperfusion injury; Cardioprotection; Ischemia; PI3K/AKT/mTOR pathway; Pharmacology; Cardiology; Mitochondrion; Coronary artery disease; Internal medicine; Apoptosis; Cell biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008975454,0.0001417016,0.0007168589,0.0002171199,0.0001122532,0.00001974646,0.0001101633,0.0001450058,0.00002406055],"category_scores_gemma":[0.00228775,0.00009840453,0.0006869131,0.001006046,0.00004623317,0.0001293116,0.0001081862,0.0004587975,0.00003037966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000436706,"about_ca_system_score_gemma":0.0002130126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000360007,"about_ca_topic_score_gemma":0.000006751864,"domain_scores_codex":[0.9976286,0.0002767633,0.0006307254,0.0001784038,0.001066451,0.0002190672],"domain_scores_gemma":[0.9978045,0.0002532039,0.0009444355,0.0002685321,0.0005970719,0.0001322334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001673202,0.00005766731,0.1440862,0.00001287271,0.0001965634,0.00000171844,0.0002863787,0.0001018056,0.830192,2.679388e-7,0.02210059,0.001290832],"study_design_scores_gemma":[0.001621519,0.001235817,0.5080307,0.000258011,0.0005350473,0.00001721515,0.0003239071,0.0002123244,0.4798237,0.00007475806,0.007714147,0.0001528765],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907188,0.00003805571,0.00007370587,0.005967653,0.002597954,0.0004988677,0.00001999995,0.00003909605,0.00004579681],"genre_scores_gemma":[0.9957023,0.00008817716,0.0002587666,0.000333041,0.0031635,0.00001461257,0.00001196756,0.0000253641,0.0004022464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3639445,"threshold_uncertainty_score":0.401282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01165295593204344,"score_gpt":0.2657435388834032,"score_spread":0.2540905829513597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}