{"id":"W4380738126","doi":"10.1016/s2352-4642(23)00127-x","title":"Association between the timing of childhood adversity and epigenetic patterns across childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective cohort","year":2023,"lang":"en","type":"article","venue":"The Lancet Child & Adolescent Health","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Minority Health and Health Disparities; National Institute of Child Health and Human Development; Australian Government; National Institute of Allergy and Infectious Diseases; Medical Research Council; University of Notre Dame Australia; National Institutes of Health; Canadian Institutes of Health Research; University of Western Australia; Government of Western Australia; Edith Cowan University; Wellcome Trust; Biotechnology and Biological Sciences Research Council; Raine Medical Research Foundation; University of Bristol; One Mind; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Economic and Social Research Council; European Commission; Curtin University of Technology; National Health and Medical Research Council; Women and Infants Research Foundation; Telethon Kids Institute","keywords":"Longitudinal study; Prospective cohort study; DNA methylation; Psychology; Cohort; Psychopathology; Life course approach; Early childhood; Cohort study; Generation R; Physical abuse; Sexual abuse; Medicine; Clinical psychology; Developmental psychology; Poison control; Injury prevention; Genetics; Biology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007953978,0.0003451424,0.0004089456,0.0005443323,0.0006840588,0.0008234704,0.0006187322,0.0006818644,0.00140603],"category_scores_gemma":[0.00157681,0.0006307764,0.0005688187,0.001358841,0.0002494938,0.0005308727,0.001089945,0.001097635,0.0001665656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004613232,"about_ca_system_score_gemma":0.0004589252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03250471,"about_ca_topic_score_gemma":0.05337743,"domain_scores_codex":[0.9995074,0.0001261374,0.00003367392,0.0001756731,0.00006075577,0.00009632823],"domain_scores_gemma":[0.9989299,0.0001289524,0.0003900133,0.000153561,0.0001645801,0.0002329593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001425864,0.00003068776,0.9976735,0.00001135465,0.0001832377,0.00005755167,0.0001663221,0.00004287879,0.0003094123,0.00006409745,0.0002797483,0.001038815],"study_design_scores_gemma":[0.000003399637,0.00002004091,0.9994583,0.000005549514,0.00003496987,0.00006896204,0.0001271235,0.00003154111,0.00003092709,0.00002102806,0.0001955808,0.000002535212],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947081,0.0009193041,0.0001948695,0.0001600017,0.00002351527,0.00000945391,0.003432032,0.000006487986,0.0005462633],"genre_scores_gemma":[0.9961099,0.0007937038,0.0003028829,0.00006935436,0.00001766201,0.00003321716,0.001870216,0.000009498751,0.0007935948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03250471,"threshold_uncertainty_score":0.06463104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0215946129653203,"score_gpt":0.2965884481010704,"score_spread":0.2749938351357502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}