{"id":"W4380738340","doi":"10.1101/2023.06.14.544834","title":"Immunogenicity of COVID-19 vaccines and their effect on the HIV reservoir in older people with HIV","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of British Columbia; York University; St. Michael's Hospital; Centre for Advancing Health Outcomes; Maple Leaf Medical Clinic; HIV Legal Network; McGill University; University of Toronto","funders":"NHLBI Division of Intramural Research; University of Toronto; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Ontario HIV Treatment Network; National Institutes of Health; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada","keywords":"Immunogenicity; Viremia; Immune system; Medicine; Vaccination; Human immunodeficiency virus (HIV); Immunology; Virology; HIV vaccine; Vaccine trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006792869,0.0002758568,0.0003546713,0.0001486929,0.0001176922,0.0002847497,0.0001998634,0.0002504046,0.0008949861],"category_scores_gemma":[0.001263029,0.0001748518,0.0003030364,0.00009877289,0.0001044932,0.0002230201,0.0003132907,0.0002750409,0.00008342823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003929973,"about_ca_system_score_gemma":0.0002394447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004761618,"about_ca_topic_score_gemma":0.003021148,"domain_scores_codex":[0.9998685,0.00005522198,0.000006267434,0.00002347984,0.00001647618,0.00003002822],"domain_scores_gemma":[0.9996746,0.0001833405,0.0000751063,0.00001928598,0.00002166343,0.0000260047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002853677,0.0005404715,0.8110179,0.0001688463,0.0003046831,0.0003919151,0.0002032529,0.1289941,0.02693556,0.0006902498,0.0003861738,0.02751325],"study_design_scores_gemma":[0.0001351459,0.003555045,0.3516358,0.00007127925,0.0001998363,0.0004662588,0.0004497488,0.6302058,0.01089621,0.001534032,0.0008244321,0.00002630984],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99893,0.00008319471,0.0006974263,0.00002584096,0.000001478446,0.000006687946,0.0001020003,0.000003907538,0.0001494797],"genre_scores_gemma":[0.9992517,0.00004787237,0.0003800757,0.00001127477,0.000001608962,0.000008993872,0.0001059037,0.000001010091,0.0001914371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004761618,"threshold_uncertainty_score":0.009467781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0274678763998648,"score_gpt":0.2853840136894854,"score_spread":0.2579161372896206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}