{"id":"W4380740576","doi":"10.1182/blood.2023020035","title":"Higher abatacept exposure after transplant decreases acute GVHD risk without increasing adverse events","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute","keywords":"Medicine; Abatacept; Internal medicine; Hazard ratio; Population; Placebo; Adverse effect; Confidence interval; Rituximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007557721,0.0002455441,0.0005775762,0.0002507432,0.0001034459,0.000634774,0.0001594454,0.0002709042,0.002790679],"category_scores_gemma":[0.001748921,0.0001170775,0.0005369229,0.0002555297,0.0001599877,0.0003022343,0.0002059184,0.000916202,0.0004845883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003129206,"about_ca_system_score_gemma":0.0003741002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003379651,"about_ca_topic_score_gemma":0.0005316561,"domain_scores_codex":[0.9994577,0.0001694172,0.00003749696,0.0001037745,0.0001372545,0.00009439365],"domain_scores_gemma":[0.9987376,0.0004256956,0.0005024406,0.0001172604,0.0000662437,0.0001508553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02649705,0.004546709,0.2280049,0.0007861288,0.001496296,0.0002411183,0.0001724311,0.0131114,0.2629508,0.0007676568,0.002610465,0.4588151],"study_design_scores_gemma":[0.001214914,0.03045863,0.8538333,0.0001358503,0.0009281454,0.001736018,0.00010828,0.0204868,0.08113474,0.001289136,0.008606119,0.00006809727],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911335,0.002306136,0.003972688,0.000160242,0.00003442083,0.00005216593,0.0002408157,0.0002235399,0.00187649],"genre_scores_gemma":[0.9978193,0.0002710812,0.001112604,0.0001298946,0.00002224631,0.00001711841,0.0001847919,0.00002078389,0.0004221114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002790679,"threshold_uncertainty_score":0.009335816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396879058283773,"score_gpt":0.2729267012297495,"score_spread":0.2589579106469118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}