{"id":"W4380740819","doi":"10.21203/rs.3.rs-3061923/v1","title":"Intranasal Immunization of Mice with a Chimeric Antigen of Cholera Toxin B and Salmonella Typhi outer membrane protein T2544 elicits protective antibodies and T cell response at the intestinal mucosa","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Victoria Park","funders":"","keywords":"Cholera toxin; Salmonella typhi; Cholera; Immunization; Microbiology; Antibody; Bacterial outer membrane; Antigen; Nasal administration; Salmonella; Antibody response; Toxin; Virology; Biology; Immunology; Bacteria; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003378514,0.0009168294,0.0003915292,0.000748755,0.0002286629,0.0003221888,0.0002439784,0.00082017,0.002208563],"category_scores_gemma":[0.0001502358,0.0002860113,0.0004556502,0.0001906537,0.0005040555,0.0002882608,0.000318166,0.001490205,0.001050111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003572992,"about_ca_system_score_gemma":0.0002702572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006367708,"about_ca_topic_score_gemma":0.0005186326,"domain_scores_codex":[0.9997564,0.00002880556,0.00001717409,0.00006672336,0.00005068644,0.00008023382],"domain_scores_gemma":[0.9997935,0.00002383561,0.00005178852,0.00002584338,0.00001727398,0.00008776283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007155719,0.0002536185,0.0002093455,0.00002874823,0.000008384456,0.00007787759,0.00002039031,0.00005375874,0.9974463,0.00009047176,0.000106662,0.00098884],"study_design_scores_gemma":[0.0003217902,0.006699637,0.007057332,0.00003200416,0.00004423458,0.00062088,0.00009859705,0.001482006,0.9797469,0.0002348287,0.003648937,0.00001285393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924421,0.0007478885,0.002244115,0.0003348211,0.0001689322,0.0000751053,0.0006024993,0.0002366309,0.003147888],"genre_scores_gemma":[0.9819909,0.0007171197,0.003042799,0.0002371343,0.00007390037,0.0001143971,0.001277657,0.0000701383,0.01247603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002208563,"threshold_uncertainty_score":0.007388353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0509858012302884,"score_gpt":0.3600125021809032,"score_spread":0.3090267009506148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}