{"id":"W4380740918","doi":"10.21203/rs.3.rs-3022604/v1","title":"Intermittent fasting reverses age- and obesity- associated adipose fibrosis through circadian reprogramming of adipose precursor cells.","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Dietary Effects on Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; St. Michael's Hospital; University of Ottawa; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ministry of Science and ICT, South Korea; Banting and Best Diabetes Centre, University of Toronto; Heart and Stroke Foundation of Canada; National Research Foundation of Korea; University of Toronto; Hospital for Sick Children; National Research Foundation","keywords":"Adipose tissue; Circadian rhythm; Reprogramming; Obesity; Endocrinology; Internal medicine; Fibrosis; Medicine; Biology; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002390791,0.0001617644,0.0002366824,0.0001451003,0.00009909148,0.0002853966,0.0001488602,0.0002583062,0.004077697],"category_scores_gemma":[0.0002758787,0.0000905039,0.0002712852,0.0001144682,0.0002147577,0.0002218574,0.000263557,0.0006402542,0.0005658808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001073835,"about_ca_system_score_gemma":0.0002526298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004530073,"about_ca_topic_score_gemma":0.0009003617,"domain_scores_codex":[0.9999267,0.00001664327,0.000004270588,0.00001824311,0.00001292591,0.00002124946],"domain_scores_gemma":[0.9998902,0.00001511377,0.00002942097,0.00002396248,0.000009772246,0.00003148752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01253346,0.0005914069,0.002671516,0.0003549936,0.0001110689,0.000252845,0.000107204,0.000316661,0.893346,0.001252109,0.004220014,0.08424275],"study_design_scores_gemma":[0.003139739,0.0123892,0.2150678,0.0002678653,0.0005053926,0.001388848,0.0009423441,0.004352408,0.6651357,0.005136489,0.09157837,0.00009586533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718695,0.01236629,0.006837848,0.001104116,0.001335,0.00004129724,0.00178014,0.0003787496,0.004287119],"genre_scores_gemma":[0.9811738,0.00488088,0.003785652,0.0003416555,0.000215403,0.00009091644,0.0009738206,0.0001368496,0.008400959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004077697,"threshold_uncertainty_score":0.0136413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1129006119875097,"score_gpt":0.4052354328493328,"score_spread":0.2923348208618231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}