{"id":"W4380763284","doi":"10.1161/circ.146.suppl_1.15328","title":"Abstract 15328: Investigating the Role of Endothelial Breast Cancer Susceptibility Gene 2 in Doxorubicin-Induced Cardiotoxicity","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"","keywords":"Cardiotoxicity; Doxorubicin; Medicine; DNA damage; Inflammation; Apoptosis; Oxidative stress; Cancer research; Umbilical vein; Cancer; Breast cancer; Endothelial stem cell; Pharmacology; Immunology; Chemotherapy; Biology; In vitro; Internal medicine; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002788273,0.0002118122,0.0002330076,0.0002840477,0.0001456516,0.0001864688,0.0001814653,0.000339138,0.002508448],"category_scores_gemma":[0.00013196,0.000122962,0.0002351946,0.0001514622,0.0001811143,0.0001790012,0.0001118047,0.0005248764,0.0004319917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002904515,"about_ca_system_score_gemma":0.0001784844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000334539,"about_ca_topic_score_gemma":0.0004584671,"domain_scores_codex":[0.9998629,0.00002652907,0.00001065599,0.00003207129,0.00003619713,0.00003162322],"domain_scores_gemma":[0.9998978,0.00002022936,0.00002698384,0.000008855422,0.00001518235,0.0000309794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003309981,0.0001403567,0.001071721,0.00007913882,0.000009947728,0.0001199818,0.00001926403,0.00006401056,0.9959317,0.0001025745,0.0001231898,0.002007082],"study_design_scores_gemma":[0.0001061006,0.002315394,0.02655419,0.00001905013,0.0000597543,0.001062686,0.00007874634,0.001248884,0.9629608,0.0001050436,0.00548155,0.000007762333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920468,0.002238956,0.002850682,0.0002611602,0.00005113626,0.00008266851,0.000754944,0.00004571689,0.001667909],"genre_scores_gemma":[0.9859671,0.00158412,0.004399843,0.0003041467,0.00002902884,0.0001750046,0.001624379,0.00002068852,0.005895695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002508448,"threshold_uncertainty_score":0.008391619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02111109375777998,"score_gpt":0.2678333791459733,"score_spread":0.2467222853881934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}