{"id":"W4380763361","doi":"10.1161/circ.146.suppl_1.15377","title":"Abstract 15377: Investigating the Role of Breast Cancer Susceptibility Gene 2 in High Glucose-Induced Endothelial Dysfunction","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiovascular Health and Risk Factors","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Enos; Umbilical vein; Downregulation and upregulation; Endothelial dysfunction; Medicine; Apoptosis; Inflammation; Oxidative stress; DNA damage; Cancer research; Transcriptome; Nitric oxide; Breast cancer; Endocrinology; Cancer; Internal medicine; Gene expression; Gene; Nitric oxide synthase; Biology; Genetics; DNA; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003284612,0.0003351699,0.0003156063,0.0002972922,0.0002132272,0.0002538038,0.0002995515,0.000449906,0.003783289],"category_scores_gemma":[0.0001072624,0.0001056095,0.0003170107,0.0003036032,0.000230284,0.0001975704,0.0001660969,0.000596239,0.0006194002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002971723,"about_ca_system_score_gemma":0.0002997321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006470026,"about_ca_topic_score_gemma":0.0005817625,"domain_scores_codex":[0.9998682,0.00003581852,0.000009003378,0.0000186323,0.00003188251,0.00003650617],"domain_scores_gemma":[0.9999349,0.00001016865,0.00001174061,0.00000521941,0.00001110428,0.00002698224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002277632,0.0006666099,0.003049717,0.0004418328,0.00005782463,0.0006475081,0.00006461337,0.0001132988,0.9796749,0.0004296848,0.001328723,0.01124771],"study_design_scores_gemma":[0.0003493734,0.006163127,0.05425003,0.00006397481,0.0001722479,0.002037828,0.0002082429,0.001019595,0.9205313,0.0002873839,0.01489973,0.00001704514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844045,0.007803378,0.001965837,0.0009624814,0.0002531268,0.0001345621,0.0008745113,0.00006193332,0.003539583],"genre_scores_gemma":[0.9769295,0.007004371,0.003435987,0.0007951788,0.0001924239,0.0002684303,0.002422118,0.00001874322,0.008933345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003783289,"threshold_uncertainty_score":0.01265633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01849051340636271,"score_gpt":0.2627703751049456,"score_spread":0.2442798616985829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}