{"id":"W4380763534","doi":"10.1016/j.psyneuen.2023.106201","title":"Selective GPER Agonist G-1 Confers Neuronal Protection and Impacts Anxiety-Like Behaviours in Ovariectomized Wistar Rats Exposed to Global Cerebral Ischemia","year":2023,"lang":"en","type":"article","venue":"Psychoneuroendocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"GPER; Corticosterone; Endocrinology; Internal medicine; Neuroprotection; Ovariectomized rat; Agonist; Ischemia; Elevated plus maze; Medicine; Estrogen; Estrogen receptor; Anxiety; Hormone; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007554969,0.0003328025,0.0003058221,0.0001521022,0.0001298356,0.00004231846,0.0001811551,0.0001978111,0.000009289854],"category_scores_gemma":[0.00009154488,0.0003382458,0.0001011774,0.0005540414,0.000155731,0.00001092743,0.0001573735,0.0003984881,0.00005099523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004981455,"about_ca_system_score_gemma":0.0001062815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001235649,"about_ca_topic_score_gemma":0.0001101583,"domain_scores_codex":[0.9976817,0.0002379309,0.000292676,0.0008545498,0.0001429211,0.0007902733],"domain_scores_gemma":[0.9992726,0.00001530488,0.00008229361,0.0003222515,0.00006435599,0.0002431803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002367878,0.000119885,0.02763845,0.00001481839,0.00007478653,0.0001124492,0.00008195398,0.00004636909,0.9628597,0.00008364474,0.005481385,0.001118712],"study_design_scores_gemma":[0.01027267,0.003326995,0.2905582,0.00003494286,0.00008279856,0.00133137,0.0001545588,0.0002427061,0.6846297,0.0001542176,0.00822977,0.0009821351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963591,0.0001304634,0.0000571478,0.001189358,0.0007699198,0.0008866817,0.00003990452,0.0001075913,0.0004598743],"genre_scores_gemma":[0.9984357,0.0002069297,0.00009373793,0.0006556382,0.0001076661,0.0001548718,0.000118676,0.0000442299,0.0001824881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.27823,"threshold_uncertainty_score":0.999907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173614015220671,"score_gpt":0.2662445150132441,"score_spread":0.2545083748610374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}