{"id":"W4380769083","doi":"10.1161/circ.146.suppl_1.9474","title":"Abstract 9474: Trim35-Mediated Ubiquitination and Degradation of Nuclear PKM2 is Sufficient to Promote Heart Failure","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"PKM2; Medicine; Ubiquitin; Ubiquitin ligase; Cell biology; Heart failure; Ventricle; Cancer research; Glycolysis; Pyruvate kinase; Internal medicine; Biology; Biochemistry; Gene; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001843539,0.0003514703,0.0003346096,0.0002396987,0.0002645514,0.0002797169,0.0002696485,0.0004941367,0.005577367],"category_scores_gemma":[0.0001274027,0.0001632046,0.0003276049,0.00012372,0.0004301537,0.0002236619,0.0002566648,0.0009080613,0.001257696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003687993,"about_ca_system_score_gemma":0.0002213334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003603942,"about_ca_topic_score_gemma":0.000562693,"domain_scores_codex":[0.9997855,0.00003177722,0.00002494588,0.00005778549,0.00004659585,0.00005346068],"domain_scores_gemma":[0.999828,0.00001882211,0.00004996448,0.00001861429,0.00001150173,0.00007306188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003774383,0.0000679064,0.0002126659,0.00006838758,0.000009867324,0.0001510845,0.00001387752,0.00004538155,0.9976239,0.00009980603,0.0002688767,0.001060776],"study_design_scores_gemma":[0.0001178295,0.00116032,0.01089655,0.00002345509,0.00004000167,0.0013916,0.00007729709,0.001091572,0.9779754,0.0001185475,0.007096547,0.00001092886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885428,0.002615955,0.003143582,0.0005443696,0.0001892055,0.00005884747,0.001661298,0.0002581854,0.002985744],"genre_scores_gemma":[0.9907487,0.0005400471,0.001297796,0.0001829343,0.00003726513,0.0000583573,0.001323679,0.00003633585,0.005774853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005577367,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009707734645684253,"score_gpt":0.2347824865462619,"score_spread":0.2250747519005777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}