{"id":"W4380769155","doi":"10.1161/circ.146.suppl_1.9501","title":"Abstract 9501: Single-Cell Transcriptomic Analysis and Patient-Specific iPSCs Reveal Dysfunctional Coronary Arterial Endothelial Cells in Hypoplastic Left Heart Syndrome","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Hypoplastic left heart syndrome; Medicine; Ventricle; Induced pluripotent stem cell; Angiogenesis; Internal medicine; Cardiology; Heart disease; Embryonic stem cell; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001438109,0.0002433305,0.000208053,0.0003285539,0.0001288033,0.0002886507,0.0001389448,0.0003026287,0.002572987],"category_scores_gemma":[0.0001315753,0.00007635887,0.0002379895,0.0001788295,0.0001556798,0.00009820292,0.0001743901,0.0003943105,0.0005279822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001033064,"about_ca_system_score_gemma":0.0001066702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003064484,"about_ca_topic_score_gemma":0.0003633067,"domain_scores_codex":[0.999871,0.00001011496,0.00001651283,0.00004257503,0.00004446876,0.00001524891],"domain_scores_gemma":[0.9999369,0.00001753196,0.00001628343,0.000009038427,0.000008808448,0.00001136441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009751679,0.00002440544,0.002830356,0.00006988172,0.00002387503,0.0008814236,0.00006499322,0.0002348263,0.9878598,0.0001936409,0.0003275654,0.007391737],"study_design_scores_gemma":[0.00004277752,0.0002639258,0.0832203,0.0000447967,0.0001569504,0.007223938,0.0001731535,0.00440175,0.892222,0.0003929608,0.01183596,0.00002144753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833882,0.0008187436,0.008286037,0.000127692,0.00004590465,0.00003975998,0.005650514,0.0001639268,0.00147925],"genre_scores_gemma":[0.9814999,0.0007406647,0.005828213,0.0001672038,0.00002262739,0.00006842158,0.008479928,0.00008532053,0.00310779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002572987,"threshold_uncertainty_score":0.008607507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339313334015952,"score_gpt":0.218466766877797,"score_spread":0.2050736335376375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}