{"id":"W4380792082","doi":"10.1101/2023.06.14.544922","title":"Transgene-Free Ex Utero Derivation of A Human Post-Implantation Embryo Model Solely from Genetically Unmodified Naïve PSCs","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Vetenskapsrådet; Center for Innovative Medicine; Karolinska Institutet; Israel Cancer Research Fund; Israel Science Foundation; Svenska Sällskapet för Medicinsk Forskning; Ragnar Söderbergs stiftelse; Flight Attendant Medical Research Institute","keywords":"Epiblast; Embryonic stem cell; Cell biology; Biology; Blastocyst; Mesoderm; Embryo; Yolk sac; Embryogenesis; Trophoblast; Stem cell; Gastrulation; Genetics; Fetus; Placenta","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004536618,0.0002565357,0.0002225417,0.0002554162,0.0001852291,0.0003532624,0.0003129047,0.0003837165,0.002433954],"category_scores_gemma":[0.0001780539,0.000196538,0.0002731835,0.0001239641,0.0002523823,0.0001985782,0.0003412012,0.000754121,0.0009518058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001372419,"about_ca_system_score_gemma":0.000310093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003777409,"about_ca_topic_score_gemma":0.0007842552,"domain_scores_codex":[0.9997756,0.00003423982,0.00003382692,0.00004420491,0.00009245758,0.00001965988],"domain_scores_gemma":[0.9998369,0.00002498631,0.00003354301,0.00005978268,0.00002186262,0.00002292903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005777672,0.00003304938,0.0002500287,0.00007315179,0.000009578182,0.0002675628,0.00005122934,0.0002212208,0.9937028,0.001031947,0.0002256674,0.004075953],"study_design_scores_gemma":[0.00002792758,0.0005651753,0.002661197,0.0000315351,0.0000621547,0.001677448,0.00004541098,0.001846266,0.9598557,0.0002593652,0.03295405,0.0000138445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8120633,0.004297107,0.1564237,0.0004451316,0.000573742,0.001181529,0.004188292,0.001422097,0.01940507],"genre_scores_gemma":[0.9284229,0.002606925,0.04862901,0.0002155085,0.00003761269,0.0004483682,0.003271013,0.0001787269,0.01618994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002433954,"threshold_uncertainty_score":0.008142412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03086733172280713,"score_gpt":0.2639861018156923,"score_spread":0.2331187700928852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}