{"id":"W4380793714","doi":"10.1161/circ.146.suppl_1.10909","title":"Abstract 10909: A Novel ATP Citrate Lyase-Dependent Metabolic-Transcriptional Axis in Pulmonary Arterial Hypertension","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Quebec - Clinical Research Organization in Cancer","funders":"","keywords":"ATP citrate lyase; Warburg effect; Downregulation and upregulation; Histone H3; PKM2; Histone H4; Cancer research; Acetylation; Apoptosis; Histone; Medicine; Biology; Glycolysis; Pyruvate kinase; Internal medicine; Biochemistry; Citrate synthase; Metabolism; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001551261,0.0005031253,0.0003687882,0.0002202411,0.0003138052,0.0004994274,0.000311052,0.0005456185,0.00833771],"category_scores_gemma":[0.00008924247,0.0001907995,0.0003960668,0.0002006316,0.0002584947,0.000258288,0.0003537014,0.0007290822,0.002063991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003195641,"about_ca_system_score_gemma":0.0004130363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003915736,"about_ca_topic_score_gemma":0.0009852997,"domain_scores_codex":[0.9998374,0.00002278444,0.00001315143,0.00005234225,0.00004248238,0.000031941],"domain_scores_gemma":[0.9999235,0.000006728893,0.00001761141,0.000004848767,0.00001376412,0.0000335884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007994269,0.0001092938,0.0007547335,0.0003012806,0.00002850813,0.0002378793,0.00002678384,0.00008353624,0.9870537,0.0007483931,0.001480142,0.008376376],"study_design_scores_gemma":[0.0007253256,0.003583107,0.1003393,0.0003396019,0.0003583042,0.004186938,0.0004361878,0.004836482,0.7518363,0.002071844,0.1312218,0.00006486575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8346415,0.06500646,0.03414874,0.004834269,0.002554756,0.000406649,0.01118538,0.001515349,0.04570685],"genre_scores_gemma":[0.9324136,0.01226146,0.0090875,0.001514453,0.0004108037,0.0003460194,0.01015337,0.0001277751,0.033685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00833771,"threshold_uncertainty_score":0.02789241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0250665617611898,"score_gpt":0.2375702685623431,"score_spread":0.2125037068011533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}