{"id":"W4380793716","doi":"10.1161/circ.146.suppl_1.10202","title":"Abstract 10202: DNA-PKcs: A Novel Therapeutic Target in Pulmonary Arterial Hypertension","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Survivin; Apoptosis; Medicine; Pulmonary hypertension; Pulmonary artery; DNA damage; Cancer research; Western blot; DNA repair; Proliferating cell nuclear antigen; Immunohistochemistry; Cell growth; Vascular resistance; Vascular smooth muscle; Pathology; Internal medicine; DNA; Cancer; Biology; Smooth muscle; Hemodynamics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000247464,0.0007658675,0.0006033504,0.0004392613,0.0002343661,0.0006593594,0.0005251692,0.0009447082,0.008737306],"category_scores_gemma":[0.0001067725,0.0001599017,0.000378462,0.0004695197,0.0002761692,0.0006199931,0.0002839797,0.001917626,0.002938033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004722614,"about_ca_system_score_gemma":0.0006809663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002965172,"about_ca_topic_score_gemma":0.000829571,"domain_scores_codex":[0.9999287,0.0000104296,0.000007233269,0.00001497607,0.00001927007,0.00001932521],"domain_scores_gemma":[0.9999452,0.0000045947,0.00001509587,0.000003076859,0.00001175273,0.00002020548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007036987,0.0025343,0.00132305,0.005598817,0.00017927,0.001194044,0.0001176068,0.0010439,0.5337047,0.004498451,0.02519541,0.4175734],"study_design_scores_gemma":[0.01058466,0.03343055,0.02529632,0.001834475,0.0008999725,0.009421256,0.0002830589,0.005345636,0.3703899,0.004769687,0.5375999,0.0001445058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3827617,0.5118142,0.01330072,0.01477096,0.006775406,0.001006968,0.00406941,0.00168328,0.06381739],"genre_scores_gemma":[0.6569639,0.2439687,0.01223676,0.004154204,0.00284325,0.0007537217,0.005687391,0.0001106726,0.0732814],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008737306,"threshold_uncertainty_score":0.02922916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04780366413095234,"score_gpt":0.2823801026818815,"score_spread":0.2345764385509291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}