{"id":"W4380793831","doi":"10.1161/circ.146.suppl_1.10715","title":"Abstract 10715: Therapeutic Efficacy of Drpitor1a, a Novel Dynamin-Related Protein 1 (DRP1) Inhibitor, in Preclinical Pulmonary Arterial Hypertension","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Medicine; Pulmonary artery; Pulmonary hypertension; Mitochondrial fission; Cardiology; Internal medicine; DNM1L; Mitochondrion; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002827489,0.000658764,0.001002717,0.0004716516,0.0001600498,0.0003197061,0.0004343074,0.0006180074,0.003033414],"category_scores_gemma":[0.000161594,0.0001787399,0.0003917124,0.0002186709,0.0003596564,0.0004402024,0.0001553034,0.001381084,0.0006333035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002724742,"about_ca_system_score_gemma":0.0005843841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004911487,"about_ca_topic_score_gemma":0.0008968782,"domain_scores_codex":[0.9998296,0.00002445374,0.00001991293,0.00003657906,0.00003435872,0.00005502774],"domain_scores_gemma":[0.999818,0.00001954943,0.00005075821,0.00001408141,0.00001925354,0.00007822755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01713989,0.006260198,0.0005218297,0.0006354692,0.000116759,0.0002305801,0.00006188532,0.0005165528,0.9482775,0.0003437961,0.001205087,0.02469045],"study_design_scores_gemma":[0.006452997,0.1328516,0.009356256,0.00009216552,0.0004034133,0.0006906312,0.00007990856,0.002488939,0.8405039,0.0001361609,0.006903329,0.0000406386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926191,0.00275595,0.0008093268,0.0002422749,0.0001508898,0.0001942216,0.001206276,0.0002032269,0.001818668],"genre_scores_gemma":[0.9882267,0.002736909,0.002003706,0.0001590669,0.00007728001,0.0003671374,0.002208401,0.00002783765,0.004192971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003033414,"threshold_uncertainty_score":0.01014775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02983943383343704,"score_gpt":0.2687612891216911,"score_spread":0.2389218552882541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}