{"id":"W4380794575","doi":"10.1161/circ.146.suppl_1.11627","title":"Abstract 11627: Genetic Testing for Hereditary Amyloid Transthyretin Amyloidosis: Insights From the Compass Program","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Medicine; Transthyretin; Amyloidosis; Genetic testing; Internal medicine; Disease; Amyloid (mycology); Gastroenterology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004825553,0.0002981699,0.0001236459,0.0009948123,0.0002593488,0.0004061036,0.0003247726,0.0003795529,0.00336827],"category_scores_gemma":[0.001477552,0.00007930288,0.0001126083,0.0005648922,0.0002197159,0.0002434653,0.0003295804,0.000332053,0.0004909068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004420012,"about_ca_system_score_gemma":0.0006287945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007657699,"about_ca_topic_score_gemma":0.008640709,"domain_scores_codex":[0.9997453,0.00006813678,0.00002356548,0.00004065988,0.00008712384,0.00003519115],"domain_scores_gemma":[0.9993569,0.0001658759,0.00007372583,0.00002031308,0.0001673245,0.0002157898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001614635,0.0002917016,0.865656,0.00005972316,0.00004360169,0.01149287,0.0003433024,0.0004312673,0.003400976,0.0003852023,0.02254668,0.09518716],"study_design_scores_gemma":[0.00007202685,0.0003770761,0.9307849,0.00028853,0.00005548733,0.03804078,0.0007768495,0.001846541,0.001200711,0.0005441336,0.02599135,0.00002177813],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9483984,0.003110221,0.001369162,0.01044752,0.0001593256,0.0001451462,0.001282694,0.0001393567,0.03494819],"genre_scores_gemma":[0.987276,0.003020495,0.002679901,0.001915991,0.0002633444,0.00003600519,0.0009661717,0.00003569707,0.0038063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007657699,"threshold_uncertainty_score":0.01522624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02413269298190675,"score_gpt":0.2650550382954858,"score_spread":0.240922345313579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}