{"id":"W4380795720","doi":"10.1161/circ.146.suppl_1.15442","title":"Abstract 15442: Pharmacological and Atrial Cardiomyocyte-Specific Inhibition of Tumor Necrosis Factor (TNF) Protects Against Adverse Atrial Remodeling and Valvular Atrial Fibrillation an a Mouse Model of Aortic Regurgitation","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"Medicine; Internal medicine; Atrial fibrillation; Fibrosis; Cardiology; Heart failure; Tumor necrosis factor alpha; Pressure overload; Volume overload; Proinflammatory cytokine; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006072695,0.00123147,0.0008469115,0.001026684,0.0003855796,0.000588957,0.0006902082,0.001383072,0.003761488],"category_scores_gemma":[0.0001835266,0.0004700675,0.000777536,0.0003380594,0.0008368185,0.0006881423,0.0002790108,0.002511148,0.001402583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003223151,"about_ca_system_score_gemma":0.0004123075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002965254,"about_ca_topic_score_gemma":0.000466681,"domain_scores_codex":[0.9992313,0.0001251604,0.0001283441,0.0001687218,0.0001835475,0.0001629821],"domain_scores_gemma":[0.999271,0.00005974098,0.0002330089,0.00008426187,0.00004798625,0.0003040432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001204775,0.0006002009,0.0001954392,0.0001000234,0.00001791474,0.000139633,0.0000397801,0.00007758748,0.9958614,0.0001700324,0.0001561974,0.001437112],"study_design_scores_gemma":[0.0008548021,0.01002893,0.006681235,0.00007957785,0.0001035634,0.001128659,0.0001425419,0.001629654,0.9736231,0.0002374877,0.005460725,0.00002969226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839349,0.002930825,0.005978082,0.0008144622,0.0003510769,0.0002499929,0.001945562,0.0006101288,0.00318486],"genre_scores_gemma":[0.9677064,0.002602733,0.008878957,0.0004806308,0.0001635561,0.0008525729,0.002419747,0.0001686048,0.01672677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003761488,"threshold_uncertainty_score":0.01258349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08183953384019949,"score_gpt":0.312965386097285,"score_spread":0.2311258522570855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}